Chirality is a key factor in the safety and efficacy of many drug products and thus the
production of single enantiomers of drug intermediates and drugs has become important …

The Curtius rearrangement is the thermal decomposition of an acyl azide derived from
carboxylic acid to produce an isocyanate as the initial product. The isocyanate can undergo …

Catecholamine‐triggered β‐adrenoceptor (β‐AR) signaling is essential for the correct
functioning of the heart. Although both β1‐and β2‐AR subtypes are expressed in …

Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a
next-generation taxoid, 1 (SB-T-1214), and camptothecin as two warheads, self-immolative …

Cardiovascular diseases (CVDs) are widespread in the modern world, and their number is
constantly growing. For a long time, CVDs have been the leading cause of morbidity and …

Because they represent attractive drug targets, adrenoceptors have been widely studied.
Recent progress in structural data of β-adrenoceptors allows us to understand and predict …

Abstract β-Blockers reduce mortality and improve symptoms in people with heart disease;
however, current clinically available β-blockers have poor selectivity for the cardiac β 1 …

An efficient synthesis of β-amino alcohols from a variety of epoxides and primary
unbranched amines in the absence of any catalyst in high yields and regioselectivities is …

Essentially employed for the treatment of airway obstructions in humans, β-agonists are also
known to have an anabolic effect in animals' skeletal muscle. In vivo and in vitro studies …

In the present work, the synthesis of new ethacrynic acid (EA) derivatives containing
nitrogen heterocyclic, urea, or thiourea moieties via efficient and practical synthetic …