Signaling pathways and intervention therapies in sepsis
Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …
systemic inflammatory and immune response to infection. Over decades, advanced …
Therapeutic targeting of the angiopoietin–TIE pathway
P Saharinen, L Eklund, K Alitalo - Nature Reviews Drug Discovery, 2017 - nature.com
The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …
permeability and pathological vascular remodelling during inflammation, tumour …
Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury
Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …
Tie1 controls angiopoietin function in vascular remodeling and inflammation
EA Korhonen, A Lampinen, H Giri… - The Journal of …, 2016 - Am Soc Clin Investig
The angiopoietin/Tie (ANG/Tie) receptor system controls developmental and tumor
angiogenesis, inflammatory vascular remodeling, and vessel leakage. ANG1 is a Tie2 …
angiogenesis, inflammatory vascular remodeling, and vessel leakage. ANG1 is a Tie2 …
Endothelial destabilization by angiopoietin-2 via integrin β1 activation
Angiopoietins regulate vascular homeostasis via the endothelial Tie receptor tyrosine
kinases. Angiopoietin-1 (Ang1) supports endothelial stabilization via Tie2 activation …
kinases. Angiopoietin-1 (Ang1) supports endothelial stabilization via Tie2 activation …
Angiopoietin–Tie signalling in the cardiovascular and lymphatic systems
L Eklund, J Kangas, P Saharinen - Clinical Science, 2017 - portlandpress.com
Endothelial cells that form the inner layer of blood and lymphatic vessels are important
regulators of vascular functions and centrally involved in the pathogenesis of vascular …
regulators of vascular functions and centrally involved in the pathogenesis of vascular …
Endothelial activation: the Ang/Tie axis in sepsis
A Leligdowicz, M Richard-Greenblatt, J Wright… - Frontiers in …, 2018 - frontiersin.org
Sepsis, a dysregulated host response to infection that causes life-threatening organ
dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis …
dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis …
Angiopoietins and Tie2 in vascular inflammation
SM Parikh - Current opinion in hematology, 2017 - journals.lww.com
Angiopoietins and Tie2 in vascular inflammation : Current Opinion in Hematology Angiopoietins
and Tie2 in vascular inflammation : Current Opinion in Hematology Log in or Register …
and Tie2 in vascular inflammation : Current Opinion in Hematology Log in or Register …
Gene control of tyrosine kinase TIE2 and vascular manifestations of infections
Ligands of the endothelial-enriched tunica interna endothelial cell kinase 2 (Tie2) are
markedly imbalanced in severe infections associated with vascular leakage, yet regulation …
markedly imbalanced in severe infections associated with vascular leakage, yet regulation …
TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis
JA Aguilar-Briseño, V Upasani, BM Ellen… - Nature …, 2020 - nature.com
Vascular permeability and plasma leakage are immune-pathologies of severe dengue virus
(DENV) infection, but the mechanisms underlying the exacerbated inflammation during …
(DENV) infection, but the mechanisms underlying the exacerbated inflammation during …