This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Phagocytosis is defined as a cellular uptake pathway for particles of greater than 0.5 μm in
diameter. Particle clearance by phagocytosis is of critical importance for tissue health and …

The inhibitory receptor PD-1 suppresses T cell activation by recruiting the phosphatase SHP-
2. However, mice with a T-cell-specific deletion of SHP-2 do not have improved antitumor …

Protein localisation and translocation between intracellular compartments underlie almost
all physiological processes. The hyperLOPIT proteomics platform combines mass …

Integrin adhesion receptors mediate the adhesion of blood cells, such as leukocytes, to
other cells, such as endothelial cells. Integrins also are critical for anchorage of …

Neutrophils are the most prevalent leukocytes in the human body. They have a pivotal role
in the innate immune response against invading bacterial and fungal pathogens, while …

Phagocytic integrins are endowed with the ability to engulf and dispose of particles of
different natures. Evolutionarily conserved from worms to humans, they are involved in …

Integrins are cell membrane receptors that are involved in essential physiological and
serious pathological processes. Their main role is to ensure a closely regulated link …

Phagocytes, which include neutrophils, monocytes, macrophages, and dendritic cells,
protect the body by removing foreign particles, bacteria, and dead or dying cells. Phagocytic …

Objective: APBB1IP is a Rap1-binding protein that mainly acts as a regulator of leukocyte
recruitment and pathogen clearance through complement-mediated phagocytosis. However …