HO-1 is the inducible form of the enzyme heme-oxygenase. HO-1 catalyzes heme
breakdown, reducing the levels of this important oxidant molecule and generating …

Acetaminophen (APAP)-induced hepatotoxicity is the main cause of drug-induced liver
injury. This study investigated the protection of baicalin and its aglycone baicalein against …

The PI3K pathway is one of the most highly perturbed cell signaling pathways in human
cancer, including the most common malignant brain tumors, gliomas, where either activating …

Coldinduced norepinephrine activates β3-adrenergic receptors (β3-AR) to stimulate the
kinase cascade and cAMP-response element-binding protein, leading to the induction of …

Introduction Preeclampsia (PE) is a pregnancy-associated complication characterised by
new-onset hypertension and proteinuria. This study explored the therapeutic potential of …

Objective We previously demonstrated the roflumilast inhibited cell proliferation and
increased cell apoptosis in ovarian cancer. In this study, we aimed to investigate the roles of …

Insights into the mechanisms by which key factors stimulate cell growth under androgen-
depleted conditions is a premise to the development of effective treatments with clinically …

Hepatic sinusoidal obstruction syndrome (HSOS) is a rare and life-threatening liver
disease.(+)-Catechin is a natural dietary flavonol with high antioxidant capacity. This study …

Dopaminergic neurons innervate extensive areas of the brain and release dopamine (DA)
onto a wide range of target neurons. However, DA release is also precisely regulated. In …

We have previously reported a novel synthetic compound KMS99220 that prevented
degeneration of the nigral dopaminergic neurons and the associated motor deficits …