Abstract The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder originally described
by Dr. Alfred Wiskott in 1937 and Dr. Robert Aldrich in 1954 as a familial disease …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

DNA double-strand breaks repaired by non-homologous end joining display limited DNA
end-processing and chromosomal mobility. By contrast, double-strand breaks undergoing …

The embryonic stem (ES) cell transcriptional and chromatin-modifying networks are critical
for self-renewal maintenance. However, it remains unclear whether these networks …

ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as
nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives …

Ras homology (RHO) GTPases are signalling proteins that have crucial roles in triggering
multiple immune functions. Through their interactions with a broad range of effectors and …

Polarization of effector CD4+ T cells can be influenced by both antigen-specific signals and
by pathogen-or adjuvant-induced cytokines, with current models attributing a dominant role …

In solid tumours, cancer cells that undergo epithelial mesenchymal transition (EMT) express
characteristic gene expression signatures that promote invasive migration as well as the …

Mesenchymal stem cells (MSCs) from adult tissues are promising candidates for
personalized cell therapy and tissue engineering. Significant progress was achieved in our …

Recent data suggest that CD8+ T-cell effector activity is an important component in the
control of HIV replication in elite controllers (ECs). One critical element of CD8+ T-cell …