Discovery and characterization of the cytokine receptor-cytokine-decoy receptor triad formed
by receptor activator of nuclear factor kappa-B ligand (RANKL)–receptor activator of NF-κB …

The role of immune system in various bone pathologies, such as osteoporosis, osteoarthritis,
and rheumatoid arthritis is now well established. This had led to the emergence of a modern …

Since the receptor activator of nuclear factor-kappa B ligand (RANKL), its cognate receptor
activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) …

Alveolar bone is a unique osseous tissue due to the proximity of dental plaque biofilms.
Periodontal health and homeostasis are mediated by a balanced host immune response to …

Osteoporosis is a major cause of fractures and associated morbidity in the aged population.
The pathogenesis of osteoporosis is multifactorial; whereas traditional pathophysiological …

The physiological role of the TNF receptor (TNFR) family member, RANK, was investigated
by generating RANK-deficient mice. RANK−/− mice were characterized by profound …

Contrary to the commonly held misconception, bone is a relatively dynamic organ that
undergoes significant turnover as compared to other organs in the body. This review details …

Osteoclasts and osteoblasts dictate skeletal mass, structure, and strength via their respective
roles in resorbing and forming bone. Bone remodeling is a spatially coordinated lifelong …

Although multiple hormones and cytokines regulate various aspects of osteoclast formation,
the final two effectors are osteoprotegerin ligand (OPG‐L)/osteoclast differentiation factor …

The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …