Rodent models for Alzheimer disease
Animal models are indispensable tools for Alzheimer disease (AD) research. Over the
course of more than two decades, an increasing number of complementary rodent models …
course of more than two decades, an increasing number of complementary rodent models …
Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder
The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …
disorder (BD), a severe mental illness arising from complex interactions between genes and …
A phase II trial of tideglusib in Alzheimer's disease
Background: The ARGO study was a phase II, double-blind, placebo controlled, four parallel
arm trial of tideglusib in Alzheimer's disease (AD). Objective: To prove the clinical efficacy of …
arm trial of tideglusib in Alzheimer's disease (AD). Objective: To prove the clinical efficacy of …
[HTML][HTML] Neurological enhancement effects of melatonin against brain injury-induced oxidative stress, neuroinflammation, and neurodegeneration via AMPK/CREB …
Oxidative stress and energy imbalance strongly correlate in neurodegenerative diseases.
Repeated concussion is becoming a serious public health issue with uncontrollable adverse …
Repeated concussion is becoming a serious public health issue with uncontrollable adverse …
Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders
OV Forlenza, VJR De-Paula… - ACS chemical …, 2014 - ACS Publications
Lithium is a well-established therapeutic option for the acute and long-term management of
bipolar disorder and major depression. More recently, based on findings from translational …
bipolar disorder and major depression. More recently, based on findings from translational …
Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup
R Diaz-Arrastia, PM Kochanek, P Bergold… - Journal of …, 2014 - liebertpub.com
Despite substantial investments by government, philanthropic, and commercial sources over
the past several decades, traumatic brain injury (TBI) remains an unmet medical need and a …
the past several decades, traumatic brain injury (TBI) remains an unmet medical need and a …
[HTML][HTML] Applications of the Morris water maze in translational traumatic brain injury research
Acquired traumatic brain injury (TBI) is frequently accompanied by persistent cognitive
symptoms, including executive function disruptions and memory deficits. The Morris Water …
symptoms, including executive function disruptions and memory deficits. The Morris Water …
Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression
Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …
The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer's disease
Alzheimer's Disease (AD) is the most common form of dementia, affecting almost 50 million
of people around the world, characterized by a complex and age-related progressive …
of people around the world, characterized by a complex and age-related progressive …
[HTML][HTML] The inflammatory continuum of traumatic brain injury and Alzheimer's disease
ON Kokiko-Cochran, JP Godbout - Frontiers in immunology, 2018 - frontiersin.org
The post-injury inflammatory response is a key mediator in long-term recovery from
traumatic brain injury (TBI). Moreover, the immune response to TBI, mediated by microglia …
traumatic brain injury (TBI). Moreover, the immune response to TBI, mediated by microglia …