BACKGROUND: The widespread availability of new computational methods and tools for
data analysis and predictive modeling requires medical informatics researchers and …

The diverse roles that Notch signals play during the development and maintenance of
normal tissues are recapitulated in different forms of cancer. Depending on the tumor type …

Purpose Clinicopathologic features and biochemical recurrence are sensitive, but not
specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a …

Background Prostate cancer is characterized by heterogeneity in the clinical course that
often does not correlate with morphologic features of the tumor. Metastasis reflects the most …

Prostate cancer (PCA) is one of the most prevalent cancers and a major leading cause of
morbidity and mortality in the Western world. The TMPRSS2-ERG fusion was recently …

Background Hypoxia is associated with a poor prognosis in prostate cancer. This work
aimed to derive and validate a hypoxia-related mRNA signature for localized prostate …

The natural history of prostate cancer is remarkably heterogeneous and, at this time, not
completely understood. The widespread adoption and application of prostate‐specific …

Prostate cancer is a leading cause of cancer death amongst males. The main clinical
dilemma in treating prostate cancer is the high number of indolent cases that confer a …

Cancer is a complex set of diseases, driven by genomic instability overlaid with epigenetic
modifications. Two prevailing concepts, the stochastic theory and the hierarchical theory, are …

The TMPRSS2–ETS fusion prostate cancers comprise 50–70% of the prostate‐specific
antigen (PSA)‐screened hospital‐based prostate cancers examined to date, making it …