Neural circuit function can be drastically affected by variations in the number of cells that are
produced during development or by a reduction in adult cell number owing to disease. For …

Astrocytes have many roles within the brain parenchyma, and a subpopulation restricted to
germinal niches functions as neural stem cells (NSCs) that produce various types of …

The diversity of cell types and regulatory states in the brain, and how these change during
aging, remains largely unknown. We present a single-cell transcriptome atlas of the entire …

We describe the development and application of methods for high-throughput
neuroanatomy in Drosophila using light microscopy. These tools enable efficient multicolor …

Radial glial progenitors (RGPs) are responsible for producing nearly all neocortical neurons.
To gain insight into the patterns of RGP division and neuron production, we quantitatively …

Transcription factors regulate the molecular, morphological, and physiological
characteristics of neurons and generate their impressive cell-type diversity. To gain insight …

The brain consists of thousands of neuronal types that are generated by stem cells
producing different neuronal types as they age. In Drosophila, this temporal patterning is …

To understand how neurons assemble to form functional circuits, it is necessary to obtain a
detailed knowledge of their diversity and to define the developmental specification programs …

The vast diversity of neurons and glia of the CNS is generated from a small, heterogeneous
population of progenitors that undergo transcriptional changes during development to …

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