Epidemiology of the classical myeloproliferative neoplasms: the four corners of an expansive and complex map

RM Shallis, R Wang, A Davidoff, X Ma, NA Podoltsev… - Blood reviews, 2020 - Elsevier
The classical myeloproliferative neoplasms (MPNs), specifically chronic myeloid leukemia
(CML), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis …

Next generation sequencing in MPNs. Lessons from the past and prospects for use as predictors of prognosis and treatment responses

V Skov - Cancers, 2020 - mdpi.com
The myeloproliferative neoplasms (MPNs) are acquired hematological stem cell neoplasms
characterized by driver mutations in JAK2, CALR, or MPL. Additive mutations may appear in …

Second cancer in Philadelphia negative myeloproliferative neoplasms (MPN-K). A nested case-control study

T Barbui, A Ghirardi, A Masciulli, A Carobbio… - Leukemia, 2019 - nature.com
We conducted a large international nested case-control study including 1881 patients with
Philadelphia-negative myeloproliferative neoplasms (MPN). Cases (n= 647) were patients …

Platelets as mediators of thromboinflammation in chronic myeloproliferative neoplasms

CP Marin Oyarzún, PG Heller - Frontiers in Immunology, 2019 - frontiersin.org
Chronic myeloproliferative neoplasms (MPN) are stem cell disorders driven by mutations in
JAK2, CALR, or MPL genes and characterized by myeloid proliferation and increased blood …

Primary analysis of JUMP, a phase 3b, expanded‐access study evaluating the safety and efficacy of ruxolitinib in patients with myelofibrosis, including those with low …

HK Al‐Ali, M Griesshammer, L Foltz… - British journal of …, 2020 - Wiley Online Library
Ruxolitinib is a potent Janus kinase (JAK) 1/JAK2 inhibitor approved for the treatment of
myelofibrosis (MF). Ruxolitinib was assessed in JUMP, a large (N= 2233), phase 3b …

Risk of infections in patients with myeloproliferative neoplasms—a population-based cohort study of 8363 patients

AR Landtblom, TML Andersson, PW Dickman… - Leukemia, 2021 - nature.com
Infections are a common complication in patients with many hematologic malignancies,
however, whether patients with myeloproliferative neoplasms (MPN) also are at an …

Characteristics of patients with myeloproliferative neoplasms with lymphoma, with or without JAK inhibitor therapy

N Pemmaraju, H Kantarjian, L Nastoupil… - Blood, The Journal …, 2019 - ashpublications.org
Characteristics of patients with myeloproliferative neoplasms with lymphoma, with or without
JAK inhibitor therapy | Blood | American Society of Hematology Skip to Main Content …

Inflammatory microenvironment and specific T cells in myeloproliferative neoplasms: immunopathogenesis and novel immunotherapies

V Nasillo, G Riva, A Paolini, F Forghieri… - International Journal of …, 2021 - mdpi.com
The Philadelphia-negative myeloproliferative neoplasms (MPNs) are malignancies of the
hematopoietic stem cell (HSC) arising as a consequence of clonal proliferation driven by …

Second cancers in MPN: Survival analysis from an international study

M Marchetti, A Ghirardi, A Masciulli… - American journal of …, 2020 - Wiley Online Library
One out of ten patients with Philadelphia‐negative myeloproliferative neoplasms (MPN)
develop a second cancer (SC): in such patients we aimed at assessing the survival impact of …

[HTML][HTML] New perspectives of interferon-alpha2 and inflammation in treating Philadelphia-negative chronic myeloproliferative neoplasms

HC Hasselbalch, RT Silver - Hemasphere, 2021 - journals.lww.com
In recent years, the use of recombinant interferon-alpha (rIFNα) as the initial treatment of the
myeloproliferative neoplasms (MPNs), essential thrombocythemia, polycythemia vera and …