[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
Global epidemiology of rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease that predominantly affects the
joints. The prevalence of RA varies globally, with generally a higher prevalence in …
joints. The prevalence of RA varies globally, with generally a higher prevalence in …
Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study
GA Gregory, TIG Robinson, SE Linklater… - The lancet Diabetes & …, 2022 - thelancet.com
Background Accurate data on type 1 diabetes prevalence, incidence, associated mortality
and life expectancy are crucial to inform public health policy, but these data are scarce. We …
and life expectancy are crucial to inform public health policy, but these data are scarce. We …
[HTML][HTML] Telomere dysfunction in ageing and age-related diseases
Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …
dysfunction. Telomere shortening and damage are recognized causes of cellular …
[HTML][HTML] mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990-2019: results from the Global Burden of Disease …
Objective To report the global, regional, and national burden of chronic obstructive
pulmonary disease (COPD) and its attributable risk factors between 1990 and 2019, by age …
pulmonary disease (COPD) and its attributable risk factors between 1990 and 2019, by age …
Depression in young people
A Thapar, O Eyre, V Patel, D Brent - The Lancet, 2022 - thelancet.com
Depression rates in young people have risen sharply in the past decade, especially in
females, which is of concern because adolescence is a period of rapid social, emotional …
females, which is of concern because adolescence is a period of rapid social, emotional …
Global prevalence of depression and elevated depressive symptoms among adolescents: A systematic review and meta‐analysis
S Shorey, ED Ng, CHJ Wong - British Journal of Clinical …, 2022 - Wiley Online Library
Objective Adolescence is a formative and turbulent phase where physiological,
psychosocial, and cognitive changes leave adolescents vulnerable to psychological …
psychosocial, and cognitive changes leave adolescents vulnerable to psychological …
Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up
Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …
substantial and rapid antidepressant effects in patients with major depressive disorder …
The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030
Cardiovascular disease is the leading cause of death in women. Decades of grassroots
campaigns have helped to raise awareness about the impact of cardiovascular disease in …
campaigns have helped to raise awareness about the impact of cardiovascular disease in …