The discovery of alternative signaling pathways that regulate cell death has revealed
multiple strategies for promoting cell death with diverse consequences at the tissue and …

Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered
when an organ undergoes a transient reduction or cessation of blood flow, followed by re …

Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

Alveolar epithelial cell damage is an important determinant of the severity of acute lung
injury/acute respiratory distress syndrome (ALI/ARDS). However, the molecular mechanisms …

Acute myocardial infarction causes lethal injury to cardiomyocytes during both ischaemia
and reperfusion (IR). It is important to define the precise mechanisms by which they die in …

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However,
the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in …

Necroptotic cell death is mediated by the most terminal known effector of the pathway,
MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by …

Necroptosis is a caspase-independent, lytic form of programmed cell death whose errant
activation has been widely implicated in many pathologies. The pathway relies on the …

The recent implication of the cell death pathway, necroptosis, in innate immunity and a
range of human pathologies has led to intense interest in the underlying molecular …

Rationale: Respiratory syncytial virus (RSV) bronchiolitis causes significant infant mortality.
Bronchiolitis is characterized by airway epithelial cell (AEC) death; however, the mode of …