Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
A Mitrofanova, S Merscher, A Fornoni - Nature Reviews Nephrology, 2023 - nature.com
Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …
prevalence. Among several pathogenetic mechanisms responsible for disease progression …
Angiopoietin-like 3 in lipoprotein metabolism
S Kersten - Nature Reviews Endocrinology, 2017 - nature.com
Triglycerides and cholesterol circulate in the bloodstream as part of various lipoprotein
particles. Three members of the angiopoietin-like (ANGPTL) protein family—ANGPTL3 …
particles. Three members of the angiopoietin-like (ANGPTL) protein family—ANGPTL3 …
Podocyte–actin dynamics in health and disease
Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …
that are involved in regulating the permselective properties of the glomerular filtration …
[HTML][HTML] Angiopoietin-like proteins: cardiovascular biology and therapeutic targeting for the prevention of cardiovascular diseases
E Thorin, P Labbé, M Lambert, P Mury… - Canadian Journal of …, 2023 - Elsevier
Despite the best pharmacologic tools available, cardiovascular diseases (CVDs) remain a
major cause of morbidity and mortality in developed countries. After 2 decades of research …
major cause of morbidity and mortality in developed countries. After 2 decades of research …
[HTML][HTML] Beyond the matrix: the many non-ECM ligands for integrins
B LaFoya, JA Munroe, A Miyamoto… - International journal of …, 2018 - mdpi.com
The traditional view of integrins portrays these highly conserved cell surface receptors as
mediators of cellular attachment to the extracellular matrix (ECM), and to a lesser degree, as …
mediators of cellular attachment to the extracellular matrix (ECM), and to a lesser degree, as …
ANGPTL3: a novel biomarker and promising therapeutic target
S Jiang, GH Qiu, N Zhu, ZY Hu, DF Liao… - Journal of drug …, 2019 - Taylor & Francis
Abstract Angiopoietin-like protein 3 (ANGPTL3) belongs to a multifunctional secreted protein
that mainly expresses in the liver, and is regulated by numerous post-translational …
that mainly expresses in the liver, and is regulated by numerous post-translational …
Rodent models to study sodium retention in experimental nephrotic syndrome
M Xiao, BN Bohnert, F Grahammer… - Acta Physiologica, 2022 - Wiley Online Library
Sodium retention and edema are hallmarks of nephrotic syndrome (NS). Different
experimental rodent models have been established for simulating NS, however, not all of …
experimental rodent models have been established for simulating NS, however, not all of …
[HTML][HTML] Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage
Q Lv, X Han, J Ni, Q Ma, R Dai, J Liu, J Liu, Y Zhai… - Cell death & …, 2022 - nature.com
Proteinuria, an indication of kidney disease, is caused by the malfunction of podocytes,
which play a key role in maintaining glomerular filtration. Angiopoietin-like 3 (ANGPTL3) has …
which play a key role in maintaining glomerular filtration. Angiopoietin-like 3 (ANGPTL3) has …
[HTML][HTML] New insights into ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases
X Su, D Peng - Lipids in Health and Disease, 2018 - Springer
Dyslipidemia, characterized by elevation of plasma low density lipoprotein cholesterol (LDL-
C), triglyceride (TG) and reduction of plasma high density lipoprotein cholesterol (HDL-C) …
C), triglyceride (TG) and reduction of plasma high density lipoprotein cholesterol (HDL-C) …
[HTML][HTML] ANGPTL3 impacts proteinuria and hyperlipidemia in primary nephrotic syndrome
F Zhong, S Liu, Y Li, G Li, M Liu, J Wang, W Cui… - Lipids in Health and …, 2022 - Springer
Background It is unclear why primary nephrotic syndrome (PNS) patients often have
dyslipidemia. Recent studies have shown that angiopoietin-like protein 3 (ANGPTL3) is an …
dyslipidemia. Recent studies have shown that angiopoietin-like protein 3 (ANGPTL3) is an …