Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …

Triglycerides and cholesterol circulate in the bloodstream as part of various lipoprotein
particles. Three members of the angiopoietin-like (ANGPTL) protein family—ANGPTL3 …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Despite the best pharmacologic tools available, cardiovascular diseases (CVDs) remain a
major cause of morbidity and mortality in developed countries. After 2 decades of research …

The traditional view of integrins portrays these highly conserved cell surface receptors as
mediators of cellular attachment to the extracellular matrix (ECM), and to a lesser degree, as …

Abstract Angiopoietin-like protein 3 (ANGPTL3) belongs to a multifunctional secreted protein
that mainly expresses in the liver, and is regulated by numerous post-translational …

Sodium retention and edema are hallmarks of nephrotic syndrome (NS). Different
experimental rodent models have been established for simulating NS, however, not all of …

Proteinuria, an indication of kidney disease, is caused by the malfunction of podocytes,
which play a key role in maintaining glomerular filtration. Angiopoietin-like 3 (ANGPTL3) has …

Dyslipidemia, characterized by elevation of plasma low density lipoprotein cholesterol (LDL-
C), triglyceride (TG) and reduction of plasma high density lipoprotein cholesterol (HDL-C) …

Background It is unclear why primary nephrotic syndrome (PNS) patients often have
dyslipidemia. Recent studies have shown that angiopoietin-like protein 3 (ANGPTL3) is an …