Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …

It is a well‐known fact that RNA is the target of a plethora of modifications which currently
amount to over a hundred. The vast majority of these modifications was observed in the two …

Wild mammalian species, including bats, constitute the natural reservoir of betacoronavirus
(including SARS, MERS, and the deadly SARS-CoV-2). Different hosts or host tissues …

Epigenetic modification plays a crucial regulatory role in the biological processes of
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …

▪ Abstract Large-genome eukaryotes use heritable cytosine methylation to silence
promoters, especially those associated with transposons and imprinted genes. Cytosine …

The extent and biological impact of RNA cytosine methylation are poorly understood, in part
owing to limitations of current techniques for determining the targets of RNA …

The sequence and the structure of DNA methyltransferase-2 (Dnmt2) bear close affinities to
authentic DNA cytosine methyltransferases. A combined genetic and biochemical approach …

DNA methyltransferases catalyze the transfer of a methyl group from S‐adenosyl‐l‐
methionine to cytosine or adenine bases in DNA. These enzymes challenge the …

The S-adenosylmethionine-dependent methyltransferase enzymes share little sequence
identity, but incorporate a highly conserved structural fold. Surprisingly, residues that bind …