The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Research on the neural substrates of drug reward, withdrawal and relapse has yet to be
translated into significant advances in the treatment of addiction. One potential reason is that …

Addiction treatment has not been appreciably improved by neuroscientific research. One
problem is that mechanistic studies using rodent models do not incorporate volitional social …

Positive, prosocial interactions are essential for survival, development, and well-being.
These intricate and complex behaviors are mediated by an amalgamation of neural circuit …

Background Several theories propose alternative explanations for drug addiction. Objectives
We propose a general theory of transition to addiction that synthesizes knowledge …

Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …

Rationale Research on adolescence and drug abuse increased substantially in the past
decade. However, drug-addiction-related behaviors following stressful experiences during …

It is difficult to translate results from animal research on addiction to an understanding of the
behavior of human drug users. Despite decades of basic research on neurobiological …

Background We recently reported that operant social choice–induced voluntary abstinence
prevents incubation of methamphetamine craving. Here, we determined whether social …

The rewarding properties of social interactions are essential for the expression of social
behavior and the development of adaptive social relationships. Here, we review sex …