Helminth parasite infections are associated with a battery of immunomodulatory
mechanisms that affect all facets of the host immune response to ensure their persistence …

Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …

According to the 'hygiene hypothesis', the decreasing incidence of infections in western
countries and more recently in developing countries is at the origin of the increasing …

Allergic rhinitis is a symptomatic disorder of the nose induced after allergen exposure by an
immunoglobulin E (IgE)-mediated inflammation of the membranes lining the nose (1). It was …

Throughout the twentieth century, there were striking increases in the incidences of many
chronic inflammatory disorders in the rich developed countries. These included autoimmune …

There is increasing interest in helminth parasite modulation of the immune system, both from
the fundamental perspective of the “arms race” between host and parasite, and equally …

Environmental variations induced by industrialization and climate change partially explain
the increase in prevalence and severity of allergic disease. One possible mechanism is the …

Deworming is rightly advocated to prevent helminth-induced morbidity. Nevertheless, in
affluent countries, the deliberate infection of patients with worms is being explored as a …

BACKGROUND: Less microbial exposure in early childhood is associated with more allergic
disease later. Allergic children have a different fecal microflora, with less lactobacilli and …

A characteristic feature of host responses to helminth infections is the development of
profound systemic and tissue-localised Type 2 immune responses that play critical roles in …