Diseases/conditions with diverse etiology, such as hemoglobinopathies, hereditary
hemochromatosis and menopause, could lead to chronic iron accumulation. This condition …

Increased survival in patients with β thalassemia major (TM) allowed for several
complications of the disease and its treatment to manifest, one of which is bone disease …

The pathogenesis of bone resorption in β-thalassemia major is multifactorial and our
understanding of the underlying molecular and cellular mechanisms remains incomplete …

Thalassemia-associated osteoporosis constitutes a major complication in patients with
thalassemia. This review presents the existing studies on the treatment of thalassemia …

Beta thalassaemia major (TM), a potentially fatal haemoglobinopathy, has transformed from
a fatal to a chronic disease in the last 30 years following the introduction of effective …

Study Design. Literature review. Objective. To present a comprehensive overview of spinal
involvement in patients with β-thalassemia, aiming to orient the spinal surgeon to these …

Previous reports using dual x-ray absorptiometry (DXA) suggest that up to 70% of adults with
thalassemia major (Thal) have low bone mass. However, few studies have controlled for …

Introduction Iron overload, a state with excessive iron storage in the body, is a common
complication in thalassemia patients which leads to multiple organ dysfunctions including …

Zoledronate is a promising bisphosphonate that improves the bone mineral density by 0.69
standard deviations in thalassemia-induced osteoporosis, but the entire range of its actions …

Objective Postprandial suppression of bone resorption is considered one of the main
contributors in the circadian rhythm of bone turnover markers. The aim of this study was to …