Urothelial carcinoma of the bladder is unique among epithelial carcinomas in its divergent
pathways of tumorigenesis. Low-grade papillary tumours rarely become muscle-invasive …

Cancer of the bladder shows divergent clinical behaviour following diagnosis and it has
been proposed that two major groups of tumours exist that develop via different molecular …

Transitional cell (urothelial) carcinoma of the bladder is the second most common urologic
malignancy and is one of the best understood neoplasms, with relatively well-defined …

Despite the fact that the current histopathologic classification for bladder cancer has led to
improved concepts for the clinical management of the disease, key questions with regard to …

Previously, we reported germline DNA variants associated with risk of urinary bladder
cancer (UBC) in Dutch and Icelandic subjects. Here we expanded the Icelandic sample set …

BACKGROUND Bladder cancer is notable for a striking heterogeneity of disease‐specific
risks. Among the approximately 75% of incident cases found to be superficial to the …

The majority of lung cancers are caused by long term exposure to the several classes of
carcinogens present in tobacco smoke. Although a significant fraction of lung cancers in …

Makorin Ring Finger Protein 1 (MKRN1) is a transcriptional co‐regulator and an E3 ligase.
Here, we show that MKRN1 simultaneously functions as a differentially negative regulator of …

Relationships between genetic alterations, such as co-occurrence or mutual exclusivity, are
often observed in cancer, where their understanding may provide new insights into etiology …

Cancer of the urinary bladder is the second most common malignancy of the genitourinary
tract, currently accounting for up to 5% of all newly diagnosed tumours in the western world …