Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?
DB Kell, E Pretorius - Biochemical Journal, 2023 - portlandpress.com
It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …
Parkinson's Disease: Current Status, Diagnosis, and Treatment Using Nanomedicines
Parkinson's disease (PD) is a chronic, and highly neurodegenerative disorder with complex
pathological processes. The features for neuropathological identification of PD include α …
pathological processes. The features for neuropathological identification of PD include α …
Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies
W Wang, L Qu, Z Cui, F Lu, L Li… - Journal of Agricultural and …, 2023 - ACS Publications
Misfolding and subsequent fibrillogenesis of α-synuclein (αSN) significantly influence the
development of Parkinson's disease (PD). This study reports the inhibitory effect of citrus …
development of Parkinson's disease (PD). This study reports the inhibitory effect of citrus …
The relevance of synuclein autoantibodies as a biomarker for Parkinson's disease
P Garg, F Maass, SM Sundaram, B Mollenhauer… - Molecular and Cellular …, 2022 - Elsevier
Several studies have investigated if the levels of α-synuclein autoantibodies (α-syn AAb)
differ in serum of Parkinson's disease (PD) patients and healthy subjects. Reproducible …
differ in serum of Parkinson's disease (PD) patients and healthy subjects. Reproducible …
Novel naturally occurring autoantibodies attenuate α‐synuclein pathology in a mouse model of Parkinson's disease
Y Li, T Wang, L Meng, L Jin, C Liu… - Neuropathology and …, 2023 - Wiley Online Library
Aims Accumulation and propagation of pathological α‐synuclein (α‐Syn) are the major
contributing factors to the pathogenesis of Parkinson's disease (PD). Therapy to halt the …
contributing factors to the pathogenesis of Parkinson's disease (PD). Therapy to halt the …
Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons
P Garg, F Würtz, F Hobbie, K Buttgereit, A Aich… - Journal of …, 2024 - Springer
Background Presence of autoantibodies against α-synuclein (α-syn AAb) in serum of the
general population has been widely reported. That such peripheral factors may be involved …
general population has been widely reported. That such peripheral factors may be involved …
Alpha-synuclein autoimmune decline in prodromal multiple system atrophy and parkinson's disease
Multiple-system trophy (MSA) and Parkinson's Disease (PD) are both progressive,
neurodegenerative diseases characterized by neuropathological deposition of aggregated …
neurodegenerative diseases characterized by neuropathological deposition of aggregated …
The immunology of B-1 cells: from development to aging
B-1 cells have intricate biology, with distinct function, phenotype and developmental origin
from conventional B cells. They generate a B cell receptor with conserved germline …
from conventional B cells. They generate a B cell receptor with conserved germline …
Serum inflammatory profile in hereditary transthyretin amyloidosis: Mechanisms and possible therapeutic implications
M Luigetti, A Romano, V Guglielmino, MA Sciarrone… - Brain Sciences, 2022 - mdpi.com
Hereditary transthyretin (ATTRv) amyloidosis is a severe, progressive, and heterogeneous
multisystemic condition due to mutations in the TTR gene. Although multiple aspects of its …
multisystemic condition due to mutations in the TTR gene. Although multiple aspects of its …
Parkinson's disease fluid biomarkers for differential diagnosis of atypical parkinsonian syndromes
J Yang, A Idowu, L Rosenthal… - Clinical and Translational …, 2023 - Wiley Online Library
The scope of the present review is to synthesize existing literature data on fluid biomarkers
for Parkinson's disease (PD) and atypical parkinsonian syndromes (APS). Parkinsonian …
for Parkinson's disease (PD) and atypical parkinsonian syndromes (APS). Parkinsonian …