The role of PHF6 in hematopoiesis and hematologic malignancies
YA Eisa, Y Guo, FC Yang - Stem Cell Reviews and Reports, 2023 - Springer
Epigenetic regulation of gene expression represents an important mechanism in the
maintenance of stem cell function. Alterations in epigenetic regulation contribute to the …
maintenance of stem cell function. Alterations in epigenetic regulation contribute to the …
Histone H2B ubiquitylation: Connections to transcription and effects on chromatin structure
Nucleosomes are major determinants of eukaryotic genome organization and regulation.
Many studies, incorporating a diversity of experimental approaches, have been focused on …
Many studies, incorporating a diversity of experimental approaches, have been focused on …
PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression
Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated
in nearly 25% of cancers. To gain insight into the mechanisms by which SWI/SNF mutations …
in nearly 25% of cancers. To gain insight into the mechanisms by which SWI/SNF mutations …
PHF6 suppresses self-renewal of leukemic stem cells in AML
SS Jalnapurkar, AS Pawar, SS George, C Antony… - Leukemia, 2024 - nature.com
Acute myeloid leukemia is characterized by uncontrolled proliferation of self-renewing
myeloid progenitors accompanied by a differentiation arrest. PHF6 is a chromatin-binding …
myeloid progenitors accompanied by a differentiation arrest. PHF6 is a chromatin-binding …
Molecular basis for PHF7-mediated ubiquitination of histone H3
The RING-type E3 ligase has been known for over two decades, yet its diverse modes of
action are still the subject of active research. Plant homeodomain (PHD) finger protein 7 …
action are still the subject of active research. Plant homeodomain (PHD) finger protein 7 …
Reprogramming of the epigenome in neurodevelopmental disorders
The etiology of neurodevelopmental disorders (NDDs) remains a challenge for researchers.
Human brain development is tightly regulated and sensitive to cellular alterations caused by …
Human brain development is tightly regulated and sensitive to cellular alterations caused by …
The role of RING finger proteins in chromatin remodeling and biological functions
Mammalian DNA duplexes are highly condensed with different components, including
histones, enabling chromatin formation. Chromatin remodeling is involved in multiple …
histones, enabling chromatin formation. Chromatin remodeling is involved in multiple …
HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology …
E Di Giorgio, E Dalla, V Tolotto, F D'Este… - Nucleic Acids …, 2024 - academic.oup.com
Access to DNA is the first level of control in regulating gene transcription, a control that is
also critical for maintaining DNA integrity. Cellular senescence is characterized by profound …
also critical for maintaining DNA integrity. Cellular senescence is characterized by profound …
Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair
S Alvarez, AC da Silva Almeida… - Blood, The Journal …, 2022 - ashpublications.org
Abstract The Plant Homeodomain 6 gene (PHF6) encodes a nucleolar and chromatin-
associated leukemia tumor suppressor with proposed roles in transcription regulation …
associated leukemia tumor suppressor with proposed roles in transcription regulation …
Role of H2B mono-ubiquitination in the initiation and progression of cancer
S Zhou, Y Cai, X Liu, L Jin, X Wang, W Ma, T Zhang - Bulletin du Cancer, 2021 - Elsevier
Numerous epigenetic alterations are observed in cancer cells, and dysregulation of mono-
ubiquitination of histone H2B (H2Bub1) has often been linked to tumorigenesis. H2Bub1 is a …
ubiquitination of histone H2B (H2Bub1) has often been linked to tumorigenesis. H2Bub1 is a …