The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

Organic synthesis is one of the most successful and useful disciplines of science and mainly
involves the construction of carbon-carbon bond (s) and carbon-heteroatom bond (s) and …

Enantioselective synthesis with small-molecule chiral hydrogen-bond donors has emerged
as a frontier of research in the field of asymmetric catalysis. Organic chemists have …

The fundamental role of the Lewis-acid catalyst lies in the activation of the CdX bond (X) O,
NR, CR2), thereby decreasing the LUMO energy and promoting nucleophilic addition to the …

It was found that the phosphoric acid derivatives of general structure 1 serve as highly
effective catalysts for the direct addition of acetyl acetone to N-Boc-protected arylimines. The …

The term “organocatalysis” describes the acceleration of chemical reactions through the
addition of a substoichiometric quantity of an organic compound. The interest in this field has …

Hydrogen bonding is responsible for the structure of much of the world around us. The
unusual and complex properties of bulk water, the ability of proteins to fold into stable three …

Organocatalysis has captured the imagination of a significant group of synthetic chemists.
Much of the mechanistic understanding of these reactions has come from computational …

Abstract The legacy of Gilbert Newton Lewis (1875–1946) pervades the lexicon of chemical
bonding and reactivity. The power of his concept of donor–acceptor bonding is evident in the …

The synthesis of NHC‐PdCl2‐3‐chloropyridine (NHC= N‐heterocyclic carbene) complexes
from readily available starting materials in air is described. The 2, 6‐diisopropylphenyl …