Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Extracellular vesicles and immunity: at the crossroads of cell communication

N Aloi, G Drago, S Ruggieri, F Cibella… - International journal of …, 2024 - mdpi.com
Extracellular vesicles (EVs), comprising exosomes and microvesicles, are small
membranous structures secreted by nearly all cell types. They have emerged as crucial …

Malaria parasites release vesicle subpopulations with signatures of different destinations

P Abou Karam, I Rosenhek‐Goldian, T Ziv… - EMBO …, 2022 - embopress.org
Malaria is the most serious mosquito‐borne parasitic disease, caused mainly by the
intracellular parasite Plasmodium falciparum. The parasite invades human red blood cells …

The rough guide to monocytes in malaria infection

A Ortega-Pajares, SJ Rogerson - Frontiers in immunology, 2018 - frontiersin.org
While half of the world's population is at risk of malaria, the most vulnerable are still children
under five, pregnant women and returning travelers. Anopheles mosquitoes transmit malaria …

Extracellular vesicles in malaria: an agglomeration of two decades of research

T Opadokun, P Rohrbach - Malaria Journal, 2021 - Springer
Malaria is a complex parasitic disease, caused by Plasmodium spp. More than a century
after the discovery of malaria parasites, this disease continues to pose a global public health …

Role of extracellular vesicles in cellular cross talk in malaria

KA Babatunde, B Yesodha Subramanian… - Frontiers in …, 2020 - frontiersin.org
Malaria infection caused by the Plasmodium species is a complex disease in which a fine
balance between host and parasite factors determine the disease severity. While in some …

Innate immunity to malaria—the role of monocytes

KR Dobbs, JN Crabtree, AE Dent - Immunological reviews, 2020 - Wiley Online Library
Monocytes are innate immune cells essential for host protection against malaria. Upon
activation, monocytes function to help reduce parasite burden through phagocytosis …

The ESCRT-III machinery participates in the production of extracellular vesicles and protein export during Plasmodium falciparum infection

Y Avalos-Padilla, VN Georgiev, E Lantero… - PLoS …, 2021 - journals.plos.org
Infection with Plasmodium falciparum enhances extracellular vesicle (EV) production in
parasitized red blood cells (pRBCs), an important mechanism for parasite-to-parasite …

Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway

W Ye, M Chew, J Hou, F Lai, SJ Leopold, HL Loo… - PLoS …, 2018 - journals.plos.org
Natural killer (NK) cells provide the first line of defense against malaria parasite infection.
However, the molecular mechanisms through which NK cells are activated by parasites are …

Extracellular Vesicles Released by Leishmania (Leishmania) amazonensis Promote Disease Progression and Induce the Production of Different Cytokines in …

FMC Barbosa, TV Dupin, MDS Toledo… - Frontiers in …, 2018 - frontiersin.org
The extracellular vesicles (EVs) released by Leishmania can contribute to the establishment
of infection and host immunomodulation. In this study, we characterized the shedding of EVs …