Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the
most frequent type, with glioblastoma multiforme (GBM) characterized with the worst …

Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo-and
radiotherapy has limited efficacy with adverse events. Therapy with genetically engineered T …

The potential clinical application of gadolinium-neutron capture therapy (Gd-NCT) for
glioblastoma multiforme (GBM) treatment has been compromised by the fast clearance and …

Background Despite recent discoveries of new molecular targets and pathways, the search
for an effective therapy for Glioblastoma Multiforme (GBM) continues. A newly emerged field …

The chemokine CXCL12/stromal cell–derived factor-1 and its receptor CXCR4 play a major
role in tumor invasion, proliferation, and metastasis. Recently, CXCR7 was identified as a …

Chemokines and their receptors are actively involved in inflammation, immune responses,
and cancer development. Here we report the detection of CD133+ glioma stem‐like cells …

Brain tumor invasion leads to recurrence and resistance to treatment. Glioma cells invade in
distinct patterns, possibly determined by microenvironmental cues including chemokines …

Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation
and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM) …

Glioblastoma (GBM) prognosis remains dismal due in part to the invasiveness of GBM cells.
Interstitial fluid flow (IFF) has been shown to increase invasion of glioma cells in vitro …

Glioblastoma (GBM) is associated with infiltration of peritumoral (PT) parenchyma by
isolated tumor cells that leads to tumor regrowth. Recently, GBM stem-like or initiating cells …