Drosophila is a marvelous system to study the underlying principles that govern how neural
circuits govern behaviors. The scale of the fly brain (∼ 100,000 neurons) and the complexity …

Research in the fruit fly Drosophila melanogaster has led to insights in neural development,
axon guidance, ion channel function, synaptic transmission, learning and memory, diurnal …

Daily sleep cycles in humans are driven by a complex circuit within which GABAergic sleep-
promoting neurons oppose arousal. Drosophila sleep has recently been shown to be …

Many lines of evidence indicate that GABA and GABAA receptors make important
contributions to human sleep regulation. Pharmacological manipulation of these receptors …

A subset of Drosophila neurons that expresses crustacean cardioactive peptide (CCAP) has
been shown previously to make the hormone bursicon, which is required for cuticle tanning …

Drosophila has enabled important breakthroughs in K+ channel research, including
identification and first cloning of a voltage-activated K+ channel, Shaker, a founding member …

Long-term memory (LTM) requires learning-induced synthesis of new proteins allocated to
specific neurons and synapses in a neural circuit. Not all learned information, however …

Homeostatic control of neural function can be mediated by the regulation of ion channel
expression, neurotransmitter receptor abundance, or modulation of presynaptic release …

Motor-dependent anterograde transport, a process that moves cytoplasmic components from
sites of biosynthesis to sites of use within cells, is crucial in neurons with long axons …

Ion channels are the determinants of excitability; therefore, manipulation of their levels and
properties provides an opportunity for the investigator to modulate neuronal and circuit …