Gallbladder cancer is a relatively rare form of malignancy about which our knowledge is
scant. However, a unique combination of predisposing factors—including genetic …

Although the incidence of hepatolithiasis is decreasing as the pattern of gallstone disease
changes in Asia, the prevalence of hepatolithiasis is persistently high, especially in Far …

Hepatic injury induced by various toxic agents, including acetaminophen (APAP), has been
attributed, in part, to the production of proinflammatory cytokines and other mediators by …

Purpose: Myofibroblasts, which are specifically differentiated fibroblasts, are thought to play
a central role in the desmoplastic reaction, a dynamic stromal change closely associated …

Cholangiocarcinomas are devastating cancers that are increasing in both their worldwide
incidence and mortality rates. The challenges posed by these often lethal biliary tract …

Cholangiocarcinomas are enigmatic cancers (largely adenocarcinomas) arising from
cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile duct …

BACKGROUND & AIMS: MicroRNAs (miRNAs) have been implicated in the development
and progression of human cancers. We investigated the roles and mechanisms of miR-26a …

Whether aspirin use is protective against cholangiocarcinoma (CCA) remains unclear. We
determined the association between aspirin use and other risk factors for each CCA subtype …

Liver cirrhosis is a form of liver fibrosis resulting from chronic hepatitis caused by various
liver diseases, such as viral hepatitis, alcoholic liver damage, nonalcoholic steatohepatitis …

Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-
2 overexpression in tumorsis considered a predictor of more advanced stage disease and of …