Green chemistry in the synthesis of pharmaceuticals
The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …
Flow synthesis approaches to privileged scaffolds–recent routes reviewed for green and sustainable aspects
AI Alfano, M Brindisi, H Lange - Green Chemistry, 2021 - pubs.rsc.org
Privileged scaffolds as starting points toward biologically active molecules represent a
neuralgic point in drug discovery. The ability of synthetic chemists concerned with their …
neuralgic point in drug discovery. The ability of synthetic chemists concerned with their …
Process intensification for the continuous flow hydrogenation of ethyl nicotinate
T Ouchi, C Battilocchio, JM Hawkins… - … Process Research & …, 2014 - ACS Publications
Here we report a process intensification study for the selective, partial, and full
hydrogenation of ethyl nicotinate using a trickle bed reactor for meso-flow transformations …
hydrogenation of ethyl nicotinate using a trickle bed reactor for meso-flow transformations …
Organocatalytic syntheses of benzoxazoles and benzothiazoles using aryl iodide and oxone via C–H functionalization and C–O/S bond formation
An organocatalytic protocol for the syntheses of 2-substituted benzoxazoles and
benzothiazoles is described from alkyl-/arylanilides and alkyl-/arylthioanilides using 1-iodo …
benzothiazoles is described from alkyl-/arylanilides and alkyl-/arylthioanilides using 1-iodo …
Flow chemistry: towards a more sustainable heterocyclic synthesis
Flow Chemistry is a revolutionary field in Organic Chemistry. By changing the conventional
methods and apparatus applied in the chemical synthesis, flow chemistry emerges as a …
methods and apparatus applied in the chemical synthesis, flow chemistry emerges as a …
Nocarbenzoxazoles A–G, Benzoxazoles Produced by Halophilic Nocardiopsis lucentensis DSM 44048
Seven new benzoxazole derivatives, nocarbenzoxazoles A–G (1–7), were isolated from the
halophilic strain Nocardiopsis lucentensis DSM 44048. Their structures were elucidated on …
halophilic strain Nocardiopsis lucentensis DSM 44048. Their structures were elucidated on …
Visible Light Induced Synthesis of 2-Benzoxazolecarboxamides Promoted by a Conjugated Microporous Polymer
Y Zhang, R Wang, C Lu, C Ma, F Wang… - ACS Sustainable …, 2024 - ACS Publications
A new and effective protocol driven by visible light has been introduced for the first time to
synthesize 2-benzoxazolecarboxamides from benzoxazinones and amines in the presence …
synthesize 2-benzoxazolecarboxamides from benzoxazinones and amines in the presence …
Visible‐Light‐Induced Aerobic Oxidative Csp3−H Functionalization of Glycine Derivatives for 2‐Substituted Benzoxazoles
ZQ Zhu, S Liu, ZY Hu, ZB Xie, J Tang… - Advanced Synthesis & …, 2021 - Wiley Online Library
We report a simple oxidative Csp3− H functionalization reaction of glycine derivatives by
visible‐light photoredox catalysis. A wide range of glycine derivatives readily undergo the …
visible‐light photoredox catalysis. A wide range of glycine derivatives readily undergo the …
Iron-catalyzed synthesis of benzoxazoles by oxidative coupling/cyclization of phenol derivatives with benzoyl aldehyde oximes
S Gao, L Gao, H Meng, M Luo, X Zeng - Chemical Communications, 2017 - pubs.rsc.org
An iron-catalyzed oxidative coupling/cyclization reaction for the synthesis of benzoxazoles at
room temperature is reported. This reaction was enabled by an inexpensive iron (III) catalyst …
room temperature is reported. This reaction was enabled by an inexpensive iron (III) catalyst …
Match-making reactors to chemistry: a continuous manufacturing-enabled sequence to a key benzoxazole pharmaceutical intermediate
F Susanne, B Martin, M Aubry… - … process research & …, 2017 - ACS Publications
The focus of this study was to develop a chemical reaction sequence toward a key
benzoxazole building block, required for clinical manufacturing of a lead candidate in the …
benzoxazole building block, required for clinical manufacturing of a lead candidate in the …