Green chemistry in the synthesis of pharmaceuticals

S Kar, H Sanderson, K Roy, E Benfenati… - Chemical …, 2021 - ACS Publications
The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …

Flow synthesis approaches to privileged scaffolds–recent routes reviewed for green and sustainable aspects

AI Alfano, M Brindisi, H Lange - Green Chemistry, 2021 - pubs.rsc.org
Privileged scaffolds as starting points toward biologically active molecules represent a
neuralgic point in drug discovery. The ability of synthetic chemists concerned with their …

Process intensification for the continuous flow hydrogenation of ethyl nicotinate

T Ouchi, C Battilocchio, JM Hawkins… - … Process Research & …, 2014 - ACS Publications
Here we report a process intensification study for the selective, partial, and full
hydrogenation of ethyl nicotinate using a trickle bed reactor for meso-flow transformations …

Organocatalytic syntheses of benzoxazoles and benzothiazoles using aryl iodide and oxone via C–H functionalization and C–O/S bond formation

SK Alla, P Sadhu, T Punniyamurthy - The Journal of Organic …, 2014 - ACS Publications
An organocatalytic protocol for the syntheses of 2-substituted benzoxazoles and
benzothiazoles is described from alkyl-/arylanilides and alkyl-/arylthioanilides using 1-iodo …

Flow chemistry: towards a more sustainable heterocyclic synthesis

P Brandão, M Pineiro… - European Journal of …, 2019 - Wiley Online Library
Flow Chemistry is a revolutionary field in Organic Chemistry. By changing the conventional
methods and apparatus applied in the chemical synthesis, flow chemistry emerges as a …

Nocarbenzoxazoles A–G, Benzoxazoles Produced by Halophilic Nocardiopsis lucentensis DSM 44048

M Sun, X Zhang, H Hao, W Li, C Lu - Journal of Natural Products, 2015 - ACS Publications
Seven new benzoxazole derivatives, nocarbenzoxazoles A–G (1–7), were isolated from the
halophilic strain Nocardiopsis lucentensis DSM 44048. Their structures were elucidated on …

Visible Light Induced Synthesis of 2-Benzoxazolecarboxamides Promoted by a Conjugated Microporous Polymer

Y Zhang, R Wang, C Lu, C Ma, F Wang… - ACS Sustainable …, 2024 - ACS Publications
A new and effective protocol driven by visible light has been introduced for the first time to
synthesize 2-benzoxazolecarboxamides from benzoxazinones and amines in the presence …

Visible‐Light‐Induced Aerobic Oxidative Csp3−H Functionalization of Glycine Derivatives for 2‐Substituted Benzoxazoles

ZQ Zhu, S Liu, ZY Hu, ZB Xie, J Tang… - Advanced Synthesis & …, 2021 - Wiley Online Library
We report a simple oxidative Csp3− H functionalization reaction of glycine derivatives by
visible‐light photoredox catalysis. A wide range of glycine derivatives readily undergo the …

Iron-catalyzed synthesis of benzoxazoles by oxidative coupling/cyclization of phenol derivatives with benzoyl aldehyde oximes

S Gao, L Gao, H Meng, M Luo, X Zeng - Chemical Communications, 2017 - pubs.rsc.org
An iron-catalyzed oxidative coupling/cyclization reaction for the synthesis of benzoxazoles at
room temperature is reported. This reaction was enabled by an inexpensive iron (III) catalyst …

Match-making reactors to chemistry: a continuous manufacturing-enabled sequence to a key benzoxazole pharmaceutical intermediate

F Susanne, B Martin, M Aubry… - … process research & …, 2017 - ACS Publications
The focus of this study was to develop a chemical reaction sequence toward a key
benzoxazole building block, required for clinical manufacturing of a lead candidate in the …