Circulating tumor cell isolation for cancer diagnosis and prognosis
Circulating tumor cells (CTCs) are tumor cells that shed from the primary tumor and
intravasate into the peripheral blood circulation system responsible for metastasis. Sensitive …
intravasate into the peripheral blood circulation system responsible for metastasis. Sensitive …
The protein corona and its effects on nanoparticle-based drug delivery systems
H Li, Y Wang, Q Tang, D Yin, C Tang, E He, L Zou… - Acta biomaterialia, 2021 - Elsevier
In most cases, once nanoparticles (NPs) enter the blood, their surface is covered by
biological molecules, especially proteins, forming a so-called protein corona (PC). As a …
biological molecules, especially proteins, forming a so-called protein corona (PC). As a …
Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery
For systemically delivered nanoparticles to reach target tissues, they must first circulate long
enough to reach the target and extravasate there. A challenge is that the particles end up …
enough to reach the target and extravasate there. A challenge is that the particles end up …
Interplay of protein corona and immune cells controls blood residency of liposomes
F Giulimondi, L Digiacomo, D Pozzi, S Palchetti… - Nature …, 2019 - nature.com
In vivo liposomes, like other types of nanoparticles, acquire a totally new 'biological
identity'due to the formation of a biomolecular coating known as the protein corona that …
identity'due to the formation of a biomolecular coating known as the protein corona that …
Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation
The unique physicochemical properties of two-dimensional (2D) graphene oxide (GO) could
greatly benefit the biomedical field; however, recent research demonstrated that GO could …
greatly benefit the biomedical field; however, recent research demonstrated that GO could …
Mechanistic understanding of protein Corona formation around nanoparticles: old puzzles and new insights
K Nienhaus, GU Nienhaus - Small, 2023 - Wiley Online Library
Although a wide variety of nanoparticles (NPs) have been engineered for use as disease
markers or drug delivery agents, the number of nanomedicines in clinical use has hitherto …
markers or drug delivery agents, the number of nanomedicines in clinical use has hitherto …
Adsorption and unfolding of a single protein triggers nanoparticle aggregation
The response of living systems to nanoparticles is thought to depend on the protein corona,
which forms shortly after exposure to physiological fluids and which is linked to a wide array …
which forms shortly after exposure to physiological fluids and which is linked to a wide array …
Protein-gold nanoparticle interactions and their possible impact on biomedical applications
J Liu, Q Peng - Acta biomaterialia, 2017 - Elsevier
In the past few years, concerns of protein-gold nanoparticles (AuNP) interaction have been
continuously growing in numerous potential biomedical applications. Despite the advances …
continuously growing in numerous potential biomedical applications. Despite the advances …
Opsonin-Deficient Nucleoproteic Corona Endows UnPEGylated Liposomes with Stealth Properties In Vivo
F Giulimondi, E Vulpis, L Digiacomo, MV Giuli… - ACS …, 2022 - ACS Publications
For several decades, surface grafted polyethylene glycol (PEG) has been a go-to strategy for
preserving the synthetic identity of liposomes in physiological milieu and preventing …
preserving the synthetic identity of liposomes in physiological milieu and preventing …
Dispersion of nanoparticles in different media importantly determines the composition of their protein corona
K Strojan, A Leonardi, VB Bregar, I Križaj, J Svete… - PloS one, 2017 - journals.plos.org
Protein corona of nanoparticles (NPs), which forms when these particles come in to contact
with protein-containing fluids, is considered as an overlooked factor in nanomedicine …
with protein-containing fluids, is considered as an overlooked factor in nanomedicine …