Circulating tumor cell isolation for cancer diagnosis and prognosis

Z Deng, S Wu, Y Wang, D Shi - EBioMedicine, 2022 - thelancet.com
Circulating tumor cells (CTCs) are tumor cells that shed from the primary tumor and
intravasate into the peripheral blood circulation system responsible for metastasis. Sensitive …

The protein corona and its effects on nanoparticle-based drug delivery systems

H Li, Y Wang, Q Tang, D Yin, C Tang, E He, L Zou… - Acta biomaterialia, 2021 - Elsevier
In most cases, once nanoparticles (NPs) enter the blood, their surface is covered by
biological molecules, especially proteins, forming a so-called protein corona (PC). As a …

Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery

W Kim, NK Ly, Y He, Y Li, Z Yuan, Y Yeo - Advanced drug delivery reviews, 2023 - Elsevier
For systemically delivered nanoparticles to reach target tissues, they must first circulate long
enough to reach the target and extravasate there. A challenge is that the particles end up …

Interplay of protein corona and immune cells controls blood residency of liposomes

F Giulimondi, L Digiacomo, D Pozzi, S Palchetti… - Nature …, 2019 - nature.com
In vivo liposomes, like other types of nanoparticles, acquire a totally new 'biological
identity'due to the formation of a biomolecular coating known as the protein corona that …

Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation

M Xu, J Zhu, F Wang, Y Xiong, Y Wu, Q Wang… - ACS …, 2016 - ACS Publications
The unique physicochemical properties of two-dimensional (2D) graphene oxide (GO) could
greatly benefit the biomedical field; however, recent research demonstrated that GO could …

Mechanistic understanding of protein Corona formation around nanoparticles: old puzzles and new insights

K Nienhaus, GU Nienhaus - Small, 2023 - Wiley Online Library
Although a wide variety of nanoparticles (NPs) have been engineered for use as disease
markers or drug delivery agents, the number of nanomedicines in clinical use has hitherto …

Adsorption and unfolding of a single protein triggers nanoparticle aggregation

S Dominguez-Medina, L Kisley, LJ Tauzin, A Hoggard… - ACS …, 2016 - ACS Publications
The response of living systems to nanoparticles is thought to depend on the protein corona,
which forms shortly after exposure to physiological fluids and which is linked to a wide array …

Protein-gold nanoparticle interactions and their possible impact on biomedical applications

J Liu, Q Peng - Acta biomaterialia, 2017 - Elsevier
In the past few years, concerns of protein-gold nanoparticles (AuNP) interaction have been
continuously growing in numerous potential biomedical applications. Despite the advances …

Opsonin-Deficient Nucleoproteic Corona Endows UnPEGylated Liposomes with Stealth Properties In Vivo

F Giulimondi, E Vulpis, L Digiacomo, MV Giuli… - ACS …, 2022 - ACS Publications
For several decades, surface grafted polyethylene glycol (PEG) has been a go-to strategy for
preserving the synthetic identity of liposomes in physiological milieu and preventing …

Dispersion of nanoparticles in different media importantly determines the composition of their protein corona

K Strojan, A Leonardi, VB Bregar, I Križaj, J Svete… - PloS one, 2017 - journals.plos.org
Protein corona of nanoparticles (NPs), which forms when these particles come in to contact
with protein-containing fluids, is considered as an overlooked factor in nanomedicine …