The collective efforts of scientists over multiple decades have led to advancements in
molecular and cellular biology-based technologies including genetic engineering and …

In xenotransplantation, the vascular endothelium serves as the first point of contact between
the recipient's blood and the transplanted donor organ. The loss of the endothelium's ability …

Background. Xenotransplantation using pig organs is now a clinical reality. However, the
process for xenograft recipient screening lacks clarity and scientific rigor: no established …

Xenotransplantation is a promising approach to reduce organ shortage, while genetic
modification of donor pigs has significantly decreased the immunogenic burden of …

Background αGal‐deficient xenografts are protected from hyperacute rejection during
xenotransplantation but are still rejected more rapidly than allografts. Despite studies …

The 2023 IXA conference, hosted in San Diego, CA, brimmed with excitement against the
backdrop of recent innovations in both the pre‐clinical and clinical realms with several first …

Objectives The final step in the production of the human Sd (a) antigen is catalyzed by beta-
1, 4-N-acetyl-galactosamine transferase 2 (B4GALNT2). This is done by adding a N …

异种器官移植是解决人类器官短缺问题的潜在方案. 在过去的上百年里, 异种器官移植经历了
早期尝试和不断进步, 目前已进入新的高速发展阶段, 取得了一系列的成果, 但异种器官移植排斥 …

As the first layer of a xenograft interacting with the recipient's blood, endothelial cells (EC)
play a crucial role in the immune responses that ultimately determine the success of …