Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours

C Horbinski, T Berger, RJ Packer, PY Wen - Nature Reviews Neurology, 2022 - nature.com
A new edition of the WHO classification of tumours of the CNS was published in 2021.
Although the previous edition of this classification was published just 5 years earlier, in …

EANO guideline on the diagnosis and management of meningiomas

R Goldbrunner, P Stavrinou, MD Jenkinson… - Neuro …, 2021 - academic.oup.com
Meningiomas are the most common intracranial tumors. Yet, only few controlled clinical trials
have been conducted to guide clinical decision making, resulting in variations of …

Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

A Choudhury, ST Magill, CD Eaton, BC Prager… - Nature …, 2022 - nature.com
Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …

Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system

S Gritsch, TT Batchelor, LN Gonzalez Castro - Cancer, 2022 - Wiley Online Library
The 2016 revised fourth edition of the World Health Organization (WHO) classification of
central nervous system (CNS) tumors incorporated molecular features with histologic …

Integrated molecular-morphologic meningioma classification: a multicenter retrospective analysis, retrospectively and prospectively validated

SLN Maas, D Stichel, T Hielscher, P Sievers… - Journal of clinical …, 2021 - ascopubs.org
PURPOSE Meningiomas are the most frequent primary intracranial tumors. Patient outcome
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …

Meningioma: a review of epidemiology, pathology, diagnosis, treatment, and future directions

C Ogasawara, BD Philbrick, DC Adamson - Biomedicines, 2021 - mdpi.com
Meningiomas are the most common intracranial tumor, making up more than a third of all
primary central nervous system (CNS) tumors. They are mostly benign tumors that can be …

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players

X Yuan, C Larsson, D Xu - Oncogene, 2019 - nature.com
Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …

An overview of meningiomas

RA Buerki, CM Horbinski, T Kruser, PM Horowitz… - Future …, 2018 - Taylor & Francis
Meningiomas are the most common primary intracranial tumor. Important advances are
occurring in meningioma research. These are expected to accelerate, potentially leading to …

A molecularly integrated grade for meningioma

J Driver, SE Hoffman, S Tavakol, E Woodward… - Neuro …, 2022 - academic.oup.com
Background Meningiomas are the most common primary intracranial tumor in adults.
Clinical care is currently guided by the World Health Organization (WHO) grade assigned to …

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

F Sahm, D Schrimpf, D Stichel, DTW Jones… - The lancet …, 2017 - thelancet.com
Background The WHO classification of brain tumours describes 15 subtypes of meningioma.
Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III …