Trained immunity—basic concepts and contributions to immunopathology
J Ochando, WJM Mulder, JC Madsen… - Nature Reviews …, 2023 - nature.com
Trained immunity is a functional state of the innate immune response and is characterized
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …
Interferon target-gene expression and epigenomic signatures in health and disease
Multiple type I interferons and interferon-γ (IFN-γ) are expressed under physiological
conditions and are increased by stress and infections, and in autoinflammatory and …
conditions and are increased by stress and infections, and in autoinflammatory and …
The role of monocytes and macrophages in autoimmune diseases: a comprehensive review
WT Ma, F Gao, K Gu, DK Chen - Frontiers in immunology, 2019 - frontiersin.org
Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …
and are involved in regulation of the initiation, development, and resolution of many …
Deciphering the tRNA-derived small RNAs: origin, development, and future
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding
RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the …
RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the …
Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway
AR Daamen, P Bachali, KA Owen, KM Kingsmore… - Scientific reports, 2021 - nature.com
SARS-CoV2 is a previously uncharacterized coronavirus and causative agent of the COVID-
19 pandemic. The host response to SARS-CoV2 has not yet been fully delineated …
19 pandemic. The host response to SARS-CoV2 has not yet been fully delineated …
The pathogenesis of systemic lupus erythematosus: harnessing big data to understand the molecular basis of lupus
MD Catalina, KA Owen, AC Labonte, AC Grammer… - Journal of …, 2020 - Elsevier
Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that causes
damage to multiple organ systems. Despite decades of research and available murine …
damage to multiple organ systems. Despite decades of research and available murine …
Macrophage polarization and plasticity in systemic lupus erythematosus
MM Ahamada, Y Jia, X Wu - Frontiers in immunology, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks almost every
organ. The condition mostly happens to adults but is also found in children, and the latter …
organ. The condition mostly happens to adults but is also found in children, and the latter …
An introduction to machine learning and analysis of its use in rheumatic diseases
KM Kingsmore, CE Puglisi, AC Grammer… - Nature Reviews …, 2021 - nature.com
Abstract Machine learning (ML) is a computerized analytical technique that is being
increasingly employed in biomedicine. ML often provides an advantage over explicitly …
increasingly employed in biomedicine. ML often provides an advantage over explicitly …
Regulatory mechanism of M1/M2 macrophage polarization in the development of autoimmune diseases
Y Peng, M Zhou, H Yang, R Qu, Y Qiu… - Mediators of …, 2023 - Wiley Online Library
Macrophages are innate immune cells in the organism and can be found in almost tissues
and organs. They are highly plastic and heterogeneous cells and can participate in the …
and organs. They are highly plastic and heterogeneous cells and can participate in the …
Innate immune cells' contribution to systemic lupus erythematosus
AA Herrada, N Escobedo, M Iruretagoyena… - Frontiers in …, 2019 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the
presence of autoantibodies against nuclear antigens, immune complex deposition, and …
presence of autoantibodies against nuclear antigens, immune complex deposition, and …