The research field of systems biology has greatly advanced and, as a result, the concept of
network pharmacology has been developed. This advancement, in turn, has shifted the …

Abstract Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation
that plays a complex, and sometimes contrasting, role in different stages of cancer …

In preclinical models, IL-1β inhibition could enhance the efficacy of fluorouracil (5-FU). In this
phase 2 study, we assessed the activity and safety of 5-FU plus bevacizumab and anakinra …

Telomeres are involved in maintaining genomic stability. Previous studies have linked both
telomere length (TL) and telomere‐related genes with cancer. We evaluated associations …

Background Alterations in the DNA methylation pattern are a hallmark of leukemias and
lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have …

Colorectal cancer (CRC) represents one of the most common malignancies and is major
cause of cancer-related deaths worldwide. A great improvement in response rate and …

Interleukins are a group of cytokines that contribute to growth and differentiation, cell
migration, and inflammatory and anti‐inflammatory responses by the immune system. In our …

Purpose: Due to variation of outcome among cases, we sought to examine whether overall
survival in ovarian cancer was associated with common inherited variants in 227 candidate …

Abstract IL-1 and TNF-α, the two major proinflammatory cytokines, have been involved in
initiation and progression of several malignancies. They could influence the biological …

Colorectal cancer remains one of the major cancer related death despite progress in the
cytotoxic treatment of colorectal cancer (CRC) over the past decade. The introduction of …