The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

The growing interest in proteins, both in fundamental research and in drug discovery, has
fuelled demand for efficient synthetic methods to access these biomolecules. Although solid …

A historical overview of peptide chemistry from T. Curtius to E. Fischer to M. Bergmann and
L. Zervas is first presented. Next, the fundamentals of peptide synthesis with a focus on solid …

Cyclic peptides have been attracting a lot of attention in recent decades, especially in the
area of drug discovery, as more and more naturally occurring cyclic peptides with diverse …

Selenocysteine, the selenium‐containing analogue of cysteine, is the twenty‐first
proteinogenic amino acid. Since its discovery almost fifty years ago, it has been exploited in …

Conspectus Synthetic proteins are expected to go beyond the boundary of recombinant
DNA expression systems by being flexibly installed with site-specific natural or unnatural …

Deposits of the microtubule-associated protein Tau (MAPT) serve as a hallmark of
neurodegenerative diseases known as tauopathies. Numerous studies have demonstrated …

Peptide ligation chemistry has revolutionized protein science by providing access to
homogeneously modified peptides and proteins. However, lipidated polypeptides and …

Sulfur and selenium occupy a distinguished position in biology owing to their redox
activities, high nucleophilicity, and acyl transfer capabilities. Thiolated/selenolated amino …

Abstract Selenocysteine (Sec), the 21st genetically encoded amino acid, is structurally
similar to cysteine (Cys) but with a sulfur to selenium replacement. This small change …