The quiet and underappreciated rise of drug-resistant invasive fungal pathogens

A Arastehfar, C Lass-Flörl, R Garcia-Rubio… - Journal of Fungi, 2020 - mdpi.com
Human fungal pathogens are attributable to a significant economic burden and mortality
worldwide. Antifungal treatments, although limited in number, play a pivotal role in …

The high osmolarity glycerol (HOG) pathway in fungi

H Yaakoub, NS Sanchez, L Ongay-Larios… - Critical Reviews in …, 2022 - Taylor & Francis
While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …

Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection

TJ Schoen, DG Calise, JW Bok, MA Giese… - PLoS …, 2023 - journals.plos.org
Hyphal growth is essential for host colonization during Aspergillus infection. The
transcription factor ZfpA regulates A. fumigatus hyphal development including branching …

[HTML][HTML] The heat shock transcription factor HsfA is essential for thermotolerance and regulates cell wall integrity in Aspergillus fumigatus

JHTM Fabri, MC Rocha, CM Fernandes… - Frontiers in …, 2021 - frontiersin.org
The deleterious effects of human-induced climate change have long been predicted.
However, the imminent emergence and spread of new diseases, including fungal infections …

An oxylipin signal confers protection against antifungal echinocandins in pathogenic aspergilli

DG Calise, SC Park, JW Bok, GH Goldman… - Nature …, 2024 - nature.com
Aspergillus fumigatus is the leading causative agent of life-threatening invasive aspergillosis
in immunocompromised individuals. One antifungal class used to treat Aspergillus infections …

Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin

AC Colabardini, F Wang, Z Dong, L Pardeshi… - Genetics, 2022 - academic.oup.com
Aspergillus fumigatus is the main causative agent of invasive pulmonary aspergillosis (IPA),
a severe disease that affects immunosuppressed patients worldwide. The fungistatic drug …

Fungal tolerance to Congo red, a cell wall integrity stress, as a promising indicator of ecological niche

DMCG Lima, TPC Costa, T Emri, I Pócsi, B Pupin… - Fungal Biology, 2021 - Elsevier
Differential sensitivities to the cell wall stress caused by Congo red (CR) have been
observed in many fungal species. In this study, the tolerances and sensitivities to CR was …

A Transient Receptor Potential-like Calcium Ion Channel in the Filamentous Fungus Aspergillus nidulans

H Wang, Q Chen, S Zhang, L Lu - Journal of Fungi, 2021 - mdpi.com
Transient Receptor Potential (TRP) proteins constitute a superfamily that encodes
transmembrane ion channels with highly diverse permeation and gating properties …

Rapid automated antifungal susceptibility testing system for yeasts based on growth characteristics

J Yu, C He, T Wang, G Zhang, J Li, J Zhang… - Frontiers in Cellular …, 2023 - frontiersin.org
Fungal pathogens are a major threat to public health, as they are becoming increasingly
common and resistant to treatment, with only four classes of antifungal medicines currently …

Induction of Aspergillus fumigatus zinc cluster transcription factor OdrA/Mdu2 provides combined cellular responses for oxidative stress protection and multiple …

C Sasse, E Bastakis, F Bakti, AM Höfer, I Zangl… - Mbio, 2023 - Am Soc Microbiol
ABSTRACT Z inc c luster transcription f actors (Zcfs) encoding zcf genes are exclusive for
fungi and required for multiple cellular processes including metabolism and development …