Cluster headache is a debilitating primary headache disorder that affects approximately
0.1% of the population worldwide. Cluster headache attacks involve severe unilateral pain …

Several cellular and molecular mechanisms have been implicated in migraine
pathophysiology including abnormal neuronal excitability and vascular events. Drugs from …

Cooling is sensed by peripheral thermoreceptors, the main transduction mechanism of
which is probably a cold-and menthol-activated ion channel, transient receptor potential …

Activity‐dependent plasticity in nociceptive pathways has been implicated in
pathomechanisms of chronic pain syndromes. Calcitonin gene‐related peptide (CGRP) …

Capsaicin, the pungent ingredient in hot pepper, activates nociceptors to produce pain and
inflammation. However, repeated exposures of capsaicin will cause desensitization to …

Na channel NaN (Nav1. 9) produces a persistent TTX-resistant (TTX-R) current in small-
diameter neurons of dorsal root ganglia (DRG) and trigeminal ganglia. Nav1. 9-specific …

A missense mutation of the CACNA1A gene that encodes the α1A subunit of the voltage‐
dependent P/Q‐type calcium channel has been discovered in patients suffering from familial …

This article reviews some recent findings on peripheral mechanisms related to the
development of oro-facial pain after trigeminal nerve injury. Chronic injury-induced oro-facial …

A single episode of status epilepticus (se) induced in rodents by the convulsant pilocarpine,
produces, after a latent period of≥ 2 weeks, a chronic epileptic condition. During the latent …

The molecular mechanisms of migraine pain are incompletely understood, although
migraine mediators such as NGF and calcitonin gene-related peptide (CGRP) are believed …