The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …

Peptides are recognized as being highly selective, potent and relatively safe as potential
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …

The therapeutic areas of infectious diseases and oncology have benefited from abundant
scaffold diversity in natural products, able to interact with many specific targets within the cell …

Inherent susceptibility of peptides to enzymatic degradation in the gastrointestinal tract is a
key bottleneck in oral peptide drug development. Here, we present a systematic analysis of …

Covering: 2005 to 2007 Natural product and natural product-derived compounds that are
being evaluated in clinical trials or are in registration (as at 31st December 2007) have been …

Conopeptides are a diverse group of recently evolved venom peptides used for prey capture
and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with …

Venomous animals have evolved a vast array of peptide toxins for prey capture and
defence. These peptides are directed against a wide variety of pharmacological targets …

Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

The neurotransmitter acetylcholine (ACh) exerts its effects on the central nervous system
(CNS) and peripheral nervous system (PNS) through two distinct types of receptors: the …

Heilendes Gift: Peptide aus dem Gift der Kegelschnecke sind potenzielle Therapeutika zur
Behandlung von neuropathischem Schmerz. Ein Nachteil dieser Peptide ist ihre kurze …