Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …

DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

The ability to respond to genotoxic stress is a prerequisite for the successful development of
the nervous system. Mutations in various DNA repair factors can lead to human diseases …

Nucleotide excision repair (NER) is a DNA repair pathway that is responsible for removing a
variety of lesions caused by harmful UV light, chemical carcinogens, and environmental …

Our cells are constantly exposed to insults from endogenous and exogenous agents that
can introduce damage into our DNA and generate genomic instability. Many of these lesions …

True microcephaly (head circumference≤–3 SD), either primary (present at birth) or
secondary (of postnatal onset) results from an imbalance between progenitor cell production …

The underlying relation between Parkinson's disease (PD) etiopathology and its major risk
factor, aging, is largely unknown. In light of the causative link between genome stability and …

Significance: When lesions are unrepaired or there are defects in the DNA repair system,
DNA damage is often correlated to apoptosis. However, different kinds of lesions and …

Extrinsic skin aging is superimposed on intrinsic skin aging process and is due primarily to
UVR (solar ultraviolet radiation) and partly by other factors, such as infrared light, smoking …