Sulfonamides constitute an important class of drugs, with many types of pharmacological
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …

Diabetes mellitus is a worldwide impacting disorder and the ratio through which the number
of diabetic patients had increased worldwide, puts medical professionals to serious stress …

Glucokinase is a key enzyme which converts glucose into glucose‐6‐phosphate in the liver
and pancreatic cells of the human. In the liver, glucokinase promotes the synthesis of …

Background: Glucokinase (GK), a cytoplasmic enzyme catalyzes the metabolism of glucose
to glucose-6-phosphate with the help of ATP and aids in the controlling of blood glucose …

Glucokinase is one of the key enzymes for the management of diabetes mellitus. Although
the literature has reported numerous molecules for lowering the blood glucose level, still no …

DM (Diabetes Mellitus) can be divided to type 1 and type 2, but out of both, type 2 is more
predominant form of diabetes. At present approximate more than 451 million people (1 in 11 …

Abstract Background Type 1 diabetes (T1D) is a serious threat to childhood life and has
fairly complicated pathogenesis. Profound attempts have been made to enlighten the …

A series of hetero-substituted sulphonamido-benzamide derivatives which can activate
glucokinase (GK) were synthesized and screened in-vitro using Human GK activation assay …

Human glucokinase (GK) is a potentially attractive target for diabetes, playing a prominent
role in the control of glucose homeostasis. Dorzagliatin is the first GK activator (GKA) to enter …

Diabetes is one of the lifelong chronic metabolic diseases which is prevalent globally. There
is a continuous rise in the number of people suffering from this disease with time. It is …