The molecular biology of chronic myeloid leukemia

MWN Deininger, JM Goldman… - Blood, The Journal of the …, 2000 - ashpublications.org
Chronic myeloid leukemia (CML) is probably the most extensively studied human
malignancy. The discovery of the Philadelphia (Ph) chromosome in 19601 as the first …

The biology of chronic myeloid leukemia

S Faderl, M Talpaz, Z Estrov, S O'Brien… - … England Journal of …, 1999 - Mass Medical Soc
Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of transformed,
primitive hematopoietic progenitor cells. It involves myeloid, monocytic, erythroid …

14-3-3 proteins: structure, function, and regulation

H Fu, RR Subramanian… - Annual review of …, 2000 - annualreviews.org
The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all
eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of …

[HTML][HTML] Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-XL

J Zha, H Harada, E Yang, J Jockel, SJ Korsmeyer - Cell, 1996 - cell.com
Extracellular survival factors alter a cell's susceptibility to apoptosis, often through
posttranslational mechanisms. However, no consistent relationship has been established …

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

W Kolch - Biochemical Journal, 2000 - portlandpress.com
The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-
regulated kinase) pathway is at the heart of signalling networks that govern proliferation …

[HTML][HTML] Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

AJ Muslin, JW Tanner, PM Allen, AS Shaw - Cell, 1996 - cell.com
The highly conserved and ubiquitously expressed 14-3-3 family of proteins bind to a variety
of proteins involved in signal transduction and cell cycle regulation. The nature and …

Chronic myeloid leukemia—advances in biology and new approaches to treatment

JM Goldman, JV Melo - New England Journal of Medicine, 2003 - Mass Medical Soc
An extraordinary series of discoveries about chronic myeloid leukemia (CML) has made this
disease a model of the way in which bench and bedside research can unite and culminate …

14-3-3 proteins: a historic overview

A Aitken - Seminars in cancer biology, 2006 - Elsevier
This chapter includes a historic overview of 14-3-3 proteins with an emphasis on the
differences between potentially cancer-relevant isoforms on the genomic, protein and …

Crystal structure of the zeta isoform of the 14-3-3 protein

D Liu, J Bienkowska, C Petosa, RJ Collier, H Fu… - Nature, 1995 - nature.com
Abstract THE 14-3-3 family of proteins have recently been identified as regulatory elements
in intracellular signalling pathways1: 14-3-3 proteins bind to oncogene and proto-oncogene …

14‐3‐3 proteins: key regulators of cell division, signalling and apoptosis

MJ van Hemert, HY Steensma, GPH van Heusden - Bioessays, 2001 - Wiley Online Library
Abstract The 14‐3‐3 proteins constitute a family of conserved proteins present in all
eukaryotic organisms so far investigated. These proteins have attracted interest because …