The Neuropilins (Nrps) are a family of essential cell surface receptors involved in multiple
fundamental cellular signaling cascades. Nrp family members have key functions in VEGF …

Neuropilins are transmembrane glycoproteins that play important roles in cardiovascular
and neuronal development, as well as in immunological system regulations. NRP1 functions …

Abstract The Sonic Hedgehog (SHH) pathway is crucial regulator of embryonic development
and stemness. Its alteration leads to medulloblastoma (MB), the most common malignant …

The antidiabetic drug phenformin displays potent anticancer activity in different tumors, but
its mechanism of action remains elusive. Using Shh medulloblastoma as model, we show …

Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer
strategy. A number of small molecules able to block the pathway at the upstream receptor …

Abstract SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an
inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients …

The morphogen Sonic Hedgehog (SHH) patterns tissues during development by directing
cell fates in a concentration-dependent manner. The SHH signal is transmitted across the …

The aberrant activation of hedgehog (HH) signaling is a leading cause of the development
of medulloblastoma, a pediatric tumor of the cerebellum. The FDA-approved HH inhibitor …

Sonic hedgehog (Shh) signaling is critical in development and oncogenesis, but the
mechanisms regulating this pathway remain unclear. Although protein phosphorylation …

Alterations in Hedgehog (Hh) signaling lead to birth defects and cancers including
medulloblastoma, the most common pediatric brain tumor. Although inhibitors targeting the …