Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …

Mitochondrial carriers (MCs) are a superfamily of nuclear-encoded proteins that are mostly
localized in the inner mitochondrial membrane and transport numerous metabolites …

Iron-sulfur (Fe/S) proteins are involved in a wide variety of cellular processes such as
enzymatic reactions, respiration, cofactor biosynthesis, ribosome biogenesis, regulation of …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Iron is an essential element for metabolic processes intrinsic to life, and yet the properties
that make iron a necessity also make it potentially deleterious. To avoid harm, iron …

Mitoferrin 1 and mitoferrin 2 are homologous members of the mitochondrial solute carrier
family. Mitoferrin 1 is required for mitochondrial iron delivery in developing erythrocytes …

Transition metal ions are essential nutrients to all forms of life. Iron, copper, zinc,
manganese, cobalt and nickel all have unique chemical and physical properties that make …

Iron and copper are essential trace nutrients playing important roles in general health and
fertility. However, both elements are highly toxic when accumulating in large quantities …

Iron is essential for many cellular processes, but cellular iron homeostasis must be
maintained to ensure the balance of cellular signaling processes and prevent disease. Iron …

Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent.
Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate …