Bile acids are steroid-derived molecules synthesized in the liver, secreted from hepatocytes
into the bile canaliculi, and subsequently stored in the gall bladder. During the feeding, bile …

A highly modular electrochemical flow cell and its application in electroorganic synthesis is
reported. This innovative setup facilitates many aspects: an easy adjustment of electrode …

In the recent years, bile acid receptors FXR and GPBAR1 have attracted the interest of
scientific community and companies, as they proved promising targets for the treatment of …

A series of myricetin derivatives containing isoxazole were designed and synthesized. All
the synthesized compounds were characterized by NMR and HRMS. In terms of antifungal …

Antagonism of the human adenosine A3 receptor (hA3R) has potential therapeutic
application. Alchemical relative binding free energy calculations of K18 and K32 suggested …

Two regiodivergent approaches to intermolecular cyclization of 2-aminobenzothiazoles with
β-ketoesters and amides have been developed, controlled by the reagents employed. With …

A novel series of copper-activatable drugs intended for use against methicillin-sensitive
Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) were …

The efficient transformation of benzylamines into the corresponding oximes has been
described by means of a chemoenzymatic process. This strategy is based on a two-step …

Abstract d-Amino acid oxidase (DAAO) is a potential target in the treatment of schizophrenia
as its inhibition increases brain d-serine level and thus contributes to NMDA receptor …

Abstract We studied [3+ 2] cycloaddition reactions of indoles and azaindoles with various
nitrile oxides. N-Protection of indoles and azaindoles with the 4-methoxybenzyl group was …