Recent progress on bile acid receptor modulators for treatment of metabolic diseases
Y Xu - Journal of medicinal chemistry, 2016 - ACS Publications
Bile acids are steroid-derived molecules synthesized in the liver, secreted from hepatocytes
into the bile canaliculi, and subsequently stored in the gall bladder. During the feeding, bile …
into the bile canaliculi, and subsequently stored in the gall bladder. During the feeding, bile …
Highly modular flow cell for electroorganic synthesis
C Gütz, A Stenglein… - Organic Process Research …, 2017 - ACS Publications
A highly modular electrochemical flow cell and its application in electroorganic synthesis is
reported. This innovative setup facilitates many aspects: an easy adjustment of electrode …
reported. This innovative setup facilitates many aspects: an easy adjustment of electrode …
Chemistry and pharmacology of GPBAR1 and FXR selective agonists, dual agonists, and antagonists
In the recent years, bile acid receptors FXR and GPBAR1 have attracted the interest of
scientific community and companies, as they proved promising targets for the treatment of …
scientific community and companies, as they proved promising targets for the treatment of …
[HTML][HTML] Design, synthesis and bioactivity of myricetin derivatives for control of fungal disease and tobacco mosaic virus disease
X Cao, B He, F Liu, Y Zhang, L Xing, N Zhang, Y Zhou… - RSC …, 2023 - pubs.rsc.org
A series of myricetin derivatives containing isoxazole were designed and synthesized. All
the synthesized compounds were characterized by NMR and HRMS. In terms of antifungal …
the synthesized compounds were characterized by NMR and HRMS. In terms of antifungal …
Hit-to-Lead Optimization of Heterocyclic Carbonyloxycarboximidamides as Selective Antagonists at Human Adenosine A3 Receptor
X Huang, A Chorianopoulou, P Kalkounou… - Journal of Medicinal …, 2024 - ACS Publications
Antagonism of the human adenosine A3 receptor (hA3R) has potential therapeutic
application. Alchemical relative binding free energy calculations of K18 and K32 suggested …
application. Alchemical relative binding free energy calculations of K18 and K32 suggested …
[HTML][HTML] Reagent-controlled regiodivergent intermolecular cyclization of 2-aminobenzothiazoles with β-ketoesters and β-ketoamides
II Roslan, KH Ng, GK Chuah… - Beilstein Journal of …, 2017 - beilstein-journals.org
Two regiodivergent approaches to intermolecular cyclization of 2-aminobenzothiazoles with
β-ketoesters and amides have been developed, controlled by the reagents employed. With …
β-ketoesters and amides have been developed, controlled by the reagents employed. With …
Pyrazolyl Thioureas and Carbothioamides with an NNSN Motif against MSSA and MRSA
A Delpe-Acharige, M Zhang, K Eschliman, A Dalecki… - ACS …, 2021 - ACS Publications
A novel series of copper-activatable drugs intended for use against methicillin-sensitive
Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) were …
Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) were …
Novel chemoenzymatic oxidation of amines into oximes based on hydrolase-catalysed peracid formation
D Méndez-Sánchez, I Lavandera, V Gotor… - Organic & …, 2017 - pubs.rsc.org
The efficient transformation of benzylamines into the corresponding oximes has been
described by means of a chemoenzymatic process. This strategy is based on a two-step …
described by means of a chemoenzymatic process. This strategy is based on a two-step …
Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors
Abstract d-Amino acid oxidase (DAAO) is a potential target in the treatment of schizophrenia
as its inhibition increases brain d-serine level and thus contributes to NMDA receptor …
as its inhibition increases brain d-serine level and thus contributes to NMDA receptor …
[3+ 2] cycloaddition of 1-(4-Methoxybenzyl) indoles and azaindoles with nitrile oxides
R Kimura, Y Sato, K Morisaki, T Nishi - Tetrahedron, 2022 - Elsevier
Abstract We studied [3+ 2] cycloaddition reactions of indoles and azaindoles with various
nitrile oxides. N-Protection of indoles and azaindoles with the 4-methoxybenzyl group was …
nitrile oxides. N-Protection of indoles and azaindoles with the 4-methoxybenzyl group was …