Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Staphylococcus aureus has been an exceptionally successful pathogen, which is still
relevant in modern age-medicine due to its adaptability and tenacity. This bacterium may be …

Daptomycin is a highly efficient last-resort antibiotic that targets the bacterial cell membrane.
Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is …

Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to
bacterial persistence. Staphylococcus aureus, the predominant pathogen in human …

Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE
infections are difficult to treat since common therapeutic options including ampicillin and …

The increasing occurrence of antibiotic-resistant bacteria and the dwindling antibiotic
research and development pipeline have created a pressing global health crisis. Here, we …

Daptomycin is a lipopeptide antibiotic produced by the soil bacterium Streptomyces
roseosporus that is clinically used to treat severe infections with Gram-positive bacteria. In …

The genus Enterococcus consists of facultative gram-positive cocci that have been isolated
from a variety of animals, plants, and environmental sources. Although 58 species have …

Daptomycin is a cyclic lipopeptide antibiotic used for the treatment of Gram-positive
infections including complicated skin and skin structure infections, right-sided infective …

Antibiotic resistance is an imminent threat to the effective treatment of bacterial infections,
and alternative antibiotic strategies are urgently required. The golden epoch of antibiotics is …