In recent years, multiple lines of evidence from human genetic and molecular studies have
highlighted the importance of the autophagy lysosomal pathway (ALP) in Parkinson's …

Tag-assisted protein purification is a method of choice for both academic researches and
large-scale industrial demands. Application of the purification tags in the protein production …

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-
associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl …

The WWOX gene was initially discovered as a putative tumor suppressor. More recently, its
association with multiple central nervous system (CNS) pathologies has been recognized …

The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a
putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The …

Tumor progression and metastasis are the major causes of death among cancer associated
mortality. Metastatic cells acquire features of migration and invasion and usually undergo …

Simple Summary Triple-negative breast cancer (TNBC) cases constitute~ 15% of breast
cancer tumors. This subtype is characterized by the lack of hormone receptors, estrogen and …

Identification of protein interactors is fundamental to understanding their functions. Here, we
describe a modified protocol for tandem affinity purification coupled with mass spectrometry …

WWOX gene loss-of-function (LoF) has been associated with neuropathologies resulting in
developmental, epileptic, and ataxic phenotypes of varying severity based on the level of …

Shortly after its discovery in 2000, WWOX was hailed as a tumor suppressor gene. In
subsequent years of research, this function was confirmed indisputably. Majority of tumors …