Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed,
protein-serine/threonine kinases, which participate in signal transduction pathways that …

The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-
regulated kinase) pathway is at the heart of signalling networks that govern proliferation …

The BRAF kinase is mutated, typically Val 600→ Glu (V600E), to induce an active oncogenic
state in a large fraction of melanomas, thyroid cancers, hairy cell leukaemias and, to a …

Members of the myocyte enhancer factor-2 (MEF2) family of transcription factors associate
with myogenic basic helix–loop–helix transcription factors such as MyoD to activate skeletal …

MAP Kinases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In
Chemical Reviews ACS Publications. Most Trusted. Most Cited. Most Read Quick View Share …

Toll-like receptors (TLRs) and the interleukin-1 receptor superfamily (IL-1Rs) are integral to
both innate and adaptive immunity for host defence,,. These receptors share a conserved …

We have cloned and characterized a novel mammalian serine/threonine protein kinase
WNK1 (withno lysine (K)) from a rat brain cDNA library. WNK1 has 2126 amino acids and …

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase
(MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in …

The Phox and Bem1p (PB1) domain constitutes a recently recognized protein-protein
interaction domain found in the atypical protein kinase C (aPKC) isoenzymes, λ/ι-and ζPKC; …

Extracellular signal-regulated kinase 5 (ERK5), also termed big mitogen-activated protein
kinase-1 (BMK1), is the most recently identified member of the mitogen-activated protein …