Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …

Zebrafish (Danio rerio) is an excellent model to study a wide diversity of human cancers. In
this review, we provide an overview of the genetic and reverse genetic toolbox allowing the …

In this study, we used comparative genomics and developmental genetics to identify
epigenetic regulators driving oncogenesis in a zebrafish retinoblastoma 1 (rb1) somatic …

Simple Summary Discovering new strategies for cancer treatment is critical, considering that
each year millions of deaths are caused by this disease. In this sense, therapies based on …

Senescence drives the onset and severity of multiple ageing‐associated diseases and
frailty. As a result, there has been an increased interest in mechanistic studies and in the …

The uterus undergoes vascular changes during the reproductive cycle and pregnancy.
Steroid hormone deprivation induces macroautophagy/autophagy in major uterine cell …

Paediatric brain cancer is the second most common childhood cancer and is the leading
cause of cancer-related deaths in children. Despite significant advancements in the …

Cellular senescence is a ubiquitous stress response that restricts the proliferative capacity of
cells. During ageing, senescent cells accumulate in various tissues leading to a number of …

Alterations of the retinoblastoma and/or the p53 signaling network are associated with
specific cancers such as high-grade astrocytoma/glioblastoma, small-cell lung cancer …

The cellular signaling pathways underlying peripheral nerve sheath tumor (PNST) formation
are poorly understood. Hippo signaling has been recently implicated in the biology of …