Transcriptional regulation of multiciliated cell differentiation

M Lewis, TH Stracker - Seminars in cell & developmental biology, 2021 - Elsevier
Multiciliated cells (MCC) project dozens to hundreds of motile cilia from the cell surface to
generate fluid flow across epithelial surfaces or turbulence to promote the transport of …

The centrosome and the primary cilium: the yin and yang of a hybrid organelle

V Joukov, A De Nicolo - Cells, 2019 - mdpi.com
Centrosomes and primary cilia are usually considered as distinct organelles, although both
are assembled with the same evolutionary conserved, microtubule-based templates, the …

Biophysical and quantitative principles of centrosome biogenesis and structure

S Gomes Pereira, MA Dias Louro… - Annual review of cell …, 2021 - annualreviews.org
The centrosome is a main orchestrator of the animal cellular microtubule cytoskeleton.
Dissecting its structure and assembly mechanisms has been a goal of cell biologists for over …

The centrosome–diverse functions in fertilization and development across species

A Aljiboury, H Hehnly - Journal of Cell Science, 2023 - journals.biologists.com
The centrosome is a non-membrane-bound organelle that is conserved across most animal
cells and serves various functions throughout the cell cycle. In dividing cells, the centrosome …

Massive centriole production can occur in the absence of deuterosomes in multiciliated cells

O Mercey, MS Levine, GM LoMastro, P Rostaing… - Nature cell …, 2019 - nature.com
Multiciliated cells (MCCs) amplify large numbers of centrioles that convert into basal bodies,
which are required for producing multiple motile cilia. Most centrioles amplified by MCCs …

Pericentrin interacts with Kinesin-1 to drive centriole motility

MR Hannaford, R Liu, N Billington, ZT Swider… - Journal of Cell …, 2022 - rupress.org
Centrosome positioning is essential for their function. Typically, centrosomes are transported
to various cellular locations through the interaction of centrosomal microtubules (MTs) with …

[PDF][PDF] Evolution of centriole assembly

C Nabais, C Peneda, M Bettencourt-Dias - Current Biology, 2020 - cell.com
the world's oceans are the dominant source of microbial photosynthesis and oceanic
temperatures are lower and fluctuate less than temperatures on land. Indeed, biochemical …

The centrosome linker and its role in cancer and genetic disorders

A Remo, X Li, E Schiebel, M Pancione - Trends in Molecular Medicine, 2020 - cell.com
Centrosome cohesion, the joining of the two centrosomes of a cell, is increasingly
appreciated as a major regulator of cell functions such as Golgi organization and cilia …

[HTML][HTML] Experimental and natural induction of de novo centriole formation

K Takumi, D Kitagawa - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
In cycling cells, new centrioles are assembled in the vicinity of pre-existing centrioles.
Although this canonical centriole duplication is a tightly regulated process in animal cells …

Plk4 triggers autonomous de novo centriole biogenesis and maturation

C Nabais, D Pessoa, J De-Carvalho… - Journal of Cell …, 2021 - rupress.org
Centrioles form centrosomes and cilia. In most proliferating cells, centrioles assemble
through canonical duplication, which is spatially, temporally, and numerically regulated by …