Opioids acting at the mu opioid receptor (MOR) are the most effective analgesics, however
adverse side effects severely limit their use. Of particular importance, abuse liability results …

In the last years, molecular docking emerged as a powerful tool to investigate the
interactions between opioid ligands and their receptors, thus driving the design and …

Morphine and the other alkaloids found in the opium poppy plant still represent the preferred
therapeutic tools to treat severe pain in first aid protocols, as well as chronic pain. The use of …

The design and synthesis of a β-turn mimetic library as a key component of a small-molecule
library targeting the major recognition motifs involved in protein–protein interactions is …

Herein we present the expedient synthesis of endomorphin-1 analogues containing
stereoisomeric β2-homo-Freidinger lactam-like scaffolds ([Amo2] EM), and we discuss …

Recently we reported the synthesis and structure–activity study of endomorphin-1 (EM-1)
analogues containing novel, unnatural α-methylene-β-aminopropanoic acids (Map). In the …

Cyclic pentapeptide Tyr-c [D-Lys-Phe-Phe-Asp] NH 2, based on the structure of
endomorphin-2 (EM-2), which shows high affinity to the μ-opioid receptor (MOR) and a very …

Opioid peptides are neuromodulators that bind to opioid receptors and reduce pain
sensitivity. Endomorphins are among the most active endogenous opioid peptides, and they …

The increasing need for large quantities of biologically active peptides for the market
strongly raised the problem of the environmental sustainability of their synthesis. In this …

Background and Purpose Endomorphins have shown great promise as pharmaceutics for
the treatment of pain. We have previously confirmed that novel endomorphin analogues …