Dental enamel is the hardest tissue in the human body, providing external protection for the
tooth against masticatory forces, temperature changes and chemical stimuli. Once enamel is …

Dental enamel is hardest tissue in the body and is produced by dental epithelial cells
residing in the tooth. Their cell fates are tightly controlled by transcriptional programs that are …

Dental epithelial stem cells give rise to four types of dental epithelial cells: inner enamel
epithelium (IEE), outer enamel epithelium (OEE), stratum intermedium (SI), and stellate …

There is growing evidence showing that tight junctions play an important role in developing
enamel. Claudins are one of the main components of tight junctions and may have pivotal …

Organ development is dictated by the regulation of genes preferentially expressed in tissues
or cell types. Gene expression profiling and identification of specific genes in organs can …

Dental enamel, the hardest tissue in the human body, is derived from dental epithelial cell
ameloblast-secreted enamel matrices. Enamel mineralization occurs in a strictly …

The transcription factor Sox21 is expressed in the epithelium of developing teeth. The
present study aimed to determine the role of Sox21 in tooth development. We found that …

Viviparity has evolved from oviparity approximately 142 times among vertebrates. Different
theories have been proposed to explain the evolution of each of its traits in the different taxa …

Cell‐and tissue‐specific extracellular matrix (ECM) composition plays an important role in
organ development, including teeth, by regulating cell behaviors, such as cell proliferation …

Enamel is formed by the repetitive secretion of a tooth‐specific extracellular matrix and its
decomposition. Calcification of the enamel matrix via hydroxyapatite (HAP) maturation …