Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …
Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy
Traumatic brain injury (TBI) is one of the most concerning health issues in which the normal
brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of …
brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of …
Brain-wide reconstruction of inhibitory circuits after traumatic brain injury
JC Frankowski, A Tierno, S Pavani, Q Cao… - Nature …, 2022 - nature.com
Despite the fundamental importance of understanding the brain's wiring diagram, our
knowledge of how neuronal connectivity is rewired by traumatic brain injury remains …
knowledge of how neuronal connectivity is rewired by traumatic brain injury remains …
Multi-dimensional mapping of brain-derived extracellular vesicle microRNA biomarker for traumatic brain injury diagnostics
The diagnosis and prognosis of traumatic brain injury (TBI) is complicated by variability in
the type and severity of injuries and the multiple endophenotypes that describe each …
the type and severity of injuries and the multiple endophenotypes that describe each …
A mouse model of repetitive blast traumatic brain injury reveals post-trauma seizures and increased neuronal excitability
V Bugay, E Bozdemir, FA Vigil, SH Chun… - Journal of …, 2020 - liebertpub.com
Repetitive blast traumatic brain injury (TBI) affects numerous soldiers on the battlefield. Mild
TBI has been shown to have long-lasting effects with repeated injury. We have investigated …
TBI has been shown to have long-lasting effects with repeated injury. We have investigated …
Transplanted interneurons improve memory precision after traumatic brain injury
B Zhu, J Eom, RF Hunt - Nature communications, 2019 - nature.com
Repair of the traumatically injured brain has been envisioned for decades, but regenerating
new neurons at the site of brain injury has been challenging. We show GABAergic …
new neurons at the site of brain injury has been challenging. We show GABAergic …
Mechanistic and therapeutic relationships of traumatic brain injury and γ-amino-butyric acid (GABA)
JM Witkin, H Shafique, JL Smith, AM Marini… - Pharmacology & …, 2024 - Elsevier
Traumatic brain injury is a highly prevalent medical condition for which no medications
specific for the prophylaxis or treatment of the condition as a whole exist. The spectrum of …
specific for the prophylaxis or treatment of the condition as a whole exist. The spectrum of …
Adult born dentate granule cell mediated upregulation of feedback inhibition in a mouse model of traumatic brain injury
Post-traumatic epilepsy (PTE) and behavioral comorbidities frequently develop after
traumatic brain injury (TBI). Aberrant neurogenesis of dentate granule cells (DGCs) after TBI …
traumatic brain injury (TBI). Aberrant neurogenesis of dentate granule cells (DGCs) after TBI …
Selective vulnerability of hippocampal interneurons to graded traumatic brain injury
Traumatic brain injury is a major risk factor for many long-term mental health problems.
Although underlying mechanisms likely involve compromised inhibition, little is known about …
Although underlying mechanisms likely involve compromised inhibition, little is known about …
DEPDC5 as a potential therapeutic target for epilepsy
KA Myers, IE Scheffer - Expert opinion on therapeutic targets, 2017 - Taylor & Francis
ABSTRACT Introduction: Dishevelled, Egl-10 and Pleckstrin (DEP) domain-containing
protein 5 (DEPDC5) is a protein subunit of the GTPase-activating proteins towards Rags 1 …
protein 5 (DEPDC5) is a protein subunit of the GTPase-activating proteins towards Rags 1 …