Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple
organ systems and is caused by loss-of-function mutations in one of two genes: TSC1 or …

Beside cytotoxic drugs, other drugs can impact men's fertility through various mechanisms.
Via the modification of the hypothalamic–pituitary–gonadal axis hormones or by non …

Post-transplant diabetes mellitus (PTDM) is a frequent consequence of solid organ
transplantation. PTDM has been associated with greater mortality and increased infections …

Rapamycin increases lifespan in mice, but whether this represents merely inhibition of lethal
neoplastic diseases, or an overall slowing in multiple aspects of aging is currently unclear …

Rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR), has the strongest
experimental support to date as a potential anti-aging therapeutic in mammals. Unlike many …

Immunosuppressive drugs are used in the treatment of inflammatory and autoimmune
diseases, as well as in transplantation. Frequently prescribed in young people, these …

Introduction: The mTOR (mechanistic target of rapamycin, formerly known as mammalian
target of rapamycin) kinase is centrally involved in the regulation of cell growth and …

Vascular anomalies, characterized by the abnormal development or growth of blood and/or
lymphatic vessels, comprise a spectrum of diseases that have a wide range of complications …

Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder that is
characterized by cellular and tissue dysplasia in several organs. With the advent of genetic …